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Pharmacology and Toxicology > Publications

Publications

Department of Pharmacology and Toxicology

* denotes equal contribution. Names in bold indicate current and former staff of our institute.

List updated on December 20, 2024.

2024

  • Yuan Q, Verbueken D, Dinani R, Kim R, Schoger E, Morsink CD, Simkooei SA, Kemna LJM, Hjortnaes J, Kuster DWD, Boon RA, Zelarayan LC, van der Velden J, Buikema JW. Glycogen synthase kinase-3 inhibition and insulin enhance proliferation and inhibit maturation of human iPSC-derived cardiomyocytes via TCF and FOXO signaling. Stem Cell Reports. 2024 Dec 5:102371. doi: 10.1016/j.stemcr.2024.11.001. Epub ahead of print. PMID: 39642876.
  • Shumanska M, Lodygin D, Gibhardt CS, Ickes C, Stejerean-Todoran I, Krause LCM, Pahl K, Jacobs LJHC, Paluschkiwitz A, Liu S, Boshnakovska A, Voigt N, Legler TJ, Haubrock M, Mitkovski M, Poschmann G, Rehling P, Dennerlein S, Riemer J, Flügel A, Bogeski I. Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses. EMBO Rep. 2024 Dec 2. doi: 10.1038/s44319-024-00313-4 . Epub ahead of print. PMID: 39623165.
  • Derks W, Rode J, Collin S, Rost F, Heinke P, Hariharan A, Pickel L, Simonova I, Lázár E, Graham E, Jashari R, Andrä M, Jeppsson A, Salehpour M, Alkass K, Druid H, Kyriakopoulos CP, Taleb I, Shankar TS, Selzman CH, Sadek H, Jovinge S, Brusch L, Frisén J, Drakos S, Bergmann O. A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease. Circulation. 2024 Nov 21. doi: 10.1161/CIRCULATIONAHA.123.067156. Epub ahead of print. PMID: 39569515.
  • Dix M, Lilienkamp T, Luther S, Parlitz U. Influence of conduction heterogeneities on transient spatiotemporal chaos in cardiac excitable media. Phys Rev E. 2024 Oct;110(4-1):044207. doi: 10.1103/PhysRevE.110.044207. PMID: 39562914.
  • Zhang JJ, Pogwizd SM, Fukuda K, Zimmermann WH, Fan C, Hare JM, Bolli R, Menasché P. Trials and tribulations of cell therapy for heart failure: an update on ongoing trials. Nat Rev Cardiol. 2024 Nov 15. doi: 10.1038/s41569-024-01098-8. Epub ahead of print. PMID: 39548233.
  • Streckfuss-Bömeke K, Kränkel N, Maack C, Schnabel RB, Zelarayán LC, Frey N, Jezzard P, Krüger M, Lachmann N, Lutz S, Noack C, Schoger E, Schröder K, Sommerfeld LC, Steffens S, Winkels H, Würtz C, Zeller T, Rog-Zielinska EA, Kohl P. Physiologists as medical scientists: An early warning from the German academic system. Physiol Rep. 2024 Nov;12(21):e70055. doi: 10.14814/phy2.70055 . PMID: 39462686; PMCID: PMC11513198.
  • Fakuade FE, Grune J, Voigt N. Cardiac arrhythmias: the growing role of autoantibodies in diagnosis and treatment. Eur Heart J. 2024 Oct 8:ehae648. doi: 10.1093/eurheartj/ehae648. Epub ahead of print. PMID: 39378151.
  • Bloothooft M, Voigt N, de Boer TP. Addressing SARS-CoV-2 viroporins with antiarrhythmic drugs. Europace. 2024 Oct 3;26(10):euae254. doi: 10.1093/europace/euae254. PMID: 39412365; PMCID: PMC11481343.
  • Bommer T, Knierim M, Unsöld J, Riedl D, Stengel L, Paulus M, Körtl T, Liaw N, Maier LS, Streckfuss-Bömeke K, Sossalla S, Pabel S. Simulation of cardiac arrhythmias in human induced pluripotent stem cell-derived cardiomyocytes. PLoS One. 2024 Sep 27;19(9):e0310463. doi: 10.1371/journal.pone.0310463 . PMID: 39331676; PMCID: PMC11432883.
  • Ruiz-Orera J, Miller DC, Greiner J, Genehr C, Grammatikaki A, Blachut S, Mbebi J, Patone G, Myronova A, Adami E, Dewani N, Liang N, Hummel O, Muecke MB, Hildebrandt TB, Fritsch G, Schrade L, Zimmermann WH, Kondova I, Diecke S, van Heesch S, Hübner N. Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts. Nat Cardiovasc Res. 2024 Sep 24. doi: 10.1038/s44161-024-00544-7 . Epub ahead of print. PMID: 39317836.
  • Keles M, Grein S, Froese N, Wirth D, Trogisch FA, Wardman R, Hemanna S, Weinzierl N, Koch PS, Uhlig S, Lomada S, Dittrich GM, Szaroszyk M, Haustein R, Hegermann J, Martin-Garrido A, Bauersachs J, Frank D, Frey N, Bieback K, Cordero J, Dobreva G, Wieland T, Heineke J. Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling. Mol Ther Nucleic Acids. 2024 Aug 15;35(3):102306. doi: 10.1016/j.omtn.2024.102306. PMID: 39281699; PMCID: PMC11402397.
  • Kim R, Nagel SH, Liaw NY, Zimmermann WH, Zelarayán LC, Schoger E. Human induced pluripotent stem cells for live cell cycle monitoring and endogenous gene activation. Stem Cell Res. 2024 Oct;80:103531. doi: 10.1016/j.scr.2024.103531. Epub 2024 Aug 5. PMID: 39128210.
  • Yogeshwaran S, Goodarzi Hosseinabadi H, Gendy DE, Miri AK. Design considerations and biomaterials selection in embedded extrusion 3D bioprinting. Biomater Sci. 2024 Jul 24. doi: 10.1039/d4bm00550c . Epub ahead of print. PMID: 39045682.
  • Suth D, Luther S, Lilienkamp T. Chaos control in cardiac dynamics: terminating chaotic states with local minima pacing. Front Netw Physiol. 2024 Jul 3;4:1401661. doi: 10.3389/fnetp.2024.1401661 . PMID: 39022296; PMCID: PMC11252590.
  • Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L. Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome. Cell Rep. 2024 Jul 13;43(7):114448. doi: 10.1016/j.celrep.2024.114448 . Epub ahead of print. PMID: 39003740.
  • Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack C, Linke WA, Heijman J, Lehnart SE, Kensah G, Ebert A, Mason FE, Voigt N. Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation. Circulation. 2024 Jun 24. doi: 10.1161/CIRCULATIONAHA.123.066577 . Epub ahead of print. PMID: 38910563.
  • Emiliano B, Dorothee B, Iyer LM, Dorota Z, Nina F, Michael M, Lucas L, David G, Nadine S, Andreas L, Wunder J, Annika F, Lika D, Sebra R, Axel S, Alexander G, Nicole D, Gergana D, Alessandra M, Zelarayán LC, Salim AS, Robert Z. Transient stabilization of human cardiovascular progenitor cells from hPSCs in vitro reflects stage-specific heart development in vivo. Cardiovasc Res. 2024 Jun 5:cvae118. doi: 10.1093/cvr/cvae118 . Epub ahead of print. PMID: 38836637.
  • Bode D, Pronto JRD, Schiattarella GG, Voigt N. Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications. Nat Rev Cardiol. 2024 May 30. doi: 10.1038/s41569-024-01038-6 . Epub ahead of print. PMID: 38816507.
  • Mason FE, Voigt N. Through the haze: unveiling the link between smoking and atrial fibrillation. Am J Physiol Heart Circ Physiol. 2024 Jun 1;326(6):H1489-H1490. doi: 10.1152/ajpheart.00286.2024 . Epub 2024 May 17. PMID: 38758125.
  • Ghasemi Z, Alizadeh Mogadam Masouleh A, Rashki Ghaleno L, Akbarinejad V, Rezazadeh Valojerdi M, Shahverdi A. Maternal nutrition and fetal imprinting of the male progeny. Anim Reprod Sci. 2024 Apr 4;265:107470. doi: 10.1016/j.anireprosci.2024.107470. Epub ahead of print. PMID: 38657462.
  • Liutkute A, Prosser BL, Voigt N. Microtubules: highway to … arrhythmia? Cardiovasc Res. 2024 Apr 18:cvae072. doi: 10.1093/cvr/cvae072 . Epub ahead of print. PMID: 38637305.
  • Hussaini S, Mamyraiym Kyzy A, Schröder-Schetelig J, Lädke SL, Venkatesan V, Diaz-Maue L, Quiñonez Uribe RA, Richter C, Biktashev VN, Majumder R, Krinski V, Luther S. Efficient termination of cardiac arrhythmias using optogenetic resonant feedback pacing. Chaos. 2024 Mar 1;34(3):031103. doi: 10.1063/5.0191519. PMID: 38526981.
  • Sommerfeld LC, Holmes AP, Yu TY, O'Shea C, Kavanagh DM, Pike JM, Wright T, Syeda F, Aljehani A, Kew T, Cardoso VR, Kabir SN, Hepburn C, Menon PR, Broadway-Stringer S, O'Reilly M, Witten A, Fortmueller L, Lutz S, Kulle A, Gkoutos GV, Pavlovic D, Arlt W, Lavery GG, Steeds R, Gehmlich K, Stoll M, Kirchhof P, Fabritz L. Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse. J Physiol. 2024 Feb 12. doi: 10.1113/JP284597. Epub ahead of print. PMID: 38345865.
  • Knauer C, Haltern H, Schoger E, Kügler S, Roos L, Zelarayán LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L. Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants. Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. doi: 10.1016/j.omtn.2024.102123. PMID: 38333672; PMCID: PMC10851011.
  • Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP. Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line. Stem Cell Res. 2024 Mar;75:103317. doi: 10.1016/j.scr.2024.103317 . Epub 2024 Jan 28. PMID: 38295750.
  • Rapöhn M, Cyganek L, Voigt N, Hasenfuß G, Lehnart SE, Wegener JW. Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM. Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H599-H611. doi: 10.1152/ajpheart.00527.2023 . Epub 2024 Jan 5. PMID: 38180453.
  • Seibertz F, Voigt N. High throughput methods for cardiac cellular electrophysiology studies: The road to personalized medicine. Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00599.2023 . Epub ahead of print. PMID: 38276947.
  • Trogisch FA, Abouissa A, Keles M, Birke A, Fuhrmann M, Dittrich GM, Weinzierl N, Wink E, Cordero J, Elsherbiny A, Martin-Garrido A, Grein S, Hemanna S, Hofmann E, Nicin L, Bibli SI, Airik R, Kispert A, Kist R, Quanchao S, Kürschner SW, Winkler M, Gretz N, Mogler C, Korff T, Koch PS, Dimmeler S, Dobreva G, Heineke J. Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9. Sci Transl Med. 2024 Feb 28;16(736):eabq4581. doi: 10.1126/scitranslmed.abq4581 . Epub 2024 Feb 28. PMID: 38416842.
  • Bloothooft M, Verbruggen B, Seibertz F, van der Heyden MAG, Voigt N, de Boer TP. Recording ten-fold larger IKr conductances with automated patch clamping using equimolar Cs+ solutions. Front Physiol. 2024 Jan 24;15:1298340. doi: 10.3389/fphys.2024.1298340. PMID: 38328302; PMCID: PMC10847579.

2023

  • Schreiber MK, Zafeiriou MP. Generation of a fluorescent oligodendrocyte reporter line in human induced pluripotent stem cells. Stem Cell Res. 2023 Dec 21;75:103295. doi: 10.1016/j.scr.2023.103295. Epub ahead of print. PMID: 38219302.
  • Shahriyari M, Rinn M, Hofemeier AD, Babych A, Zimmermann WH, Tiburcy M. Protocol to develop force-generating human skeletal muscle organoids. STAR Protoc. 2023 Dec 20;5(1):102794. doi: 10.1016/j.xpro.2023.102794 . Epub ahead of print. PMID: 38133957.
  • Hegemann N, Barth L, Doering Y, Voigt N, Grune J. Implications for neutrophils in cardiac arrhythmias. Am J Physiol Heart Circ Physiol. 2023 Dec 15. doi: 10.1152/ajpheart.00590.2023 . Epub ahead of print. PMID: 38099844.
  • Schreiber MK, Zafeiriou MP. Generation of Pelizaeus-Merzbacher disease (PMD) mutant (PLP1-C33Y) in induced pluripotent stem cell (iPSC) by CRISPR/Cas9 genome editing. Stem Cell Res. 2023 Dec 7;74:103276. doi: 10.1016/j.scr.2023.103276. Epub ahead of print. PMID: 38104430.
  • Hussaini S, Majumder R, Krinski V, Luther S. In silico optical modulation of spiral wave trajectories in cardiac tissue. Pflugers Arch. 2023 Dec 14. doi: 10.1007/s00424-023-02889-7. Epub ahead of print. PMID: 38095694.
  • Kyriakopoulou E, Versteeg D, de Ruiter H, Perini I, Seibertz F, Döring Y, Zentilin L, Tsui H, van Kampen S, Tiburcy M, Meyer T, Voigt N, van Tintelen J, Zimmermann W, Giacca M, van Rooij E. Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy. Nat Cardiovasc Res 2, 1262–1276 (2023 Dec 07). https://doi.org/10.1038/s44161-023-00378-9.
  • de Jong-Bolm D, Sadeghi M, Bogaciu CA, Bao G, Klaehn G, Hoff M, Mittelmeier L, Basmanav FB, Opazo F, Noé F, Rizzoli SO. Protein nanobarcodes enable single-step multiplexed fluorescence imaging. PLoS Biol. 2023 Dec 11;21(12):e3002427. doi: 10.1371/journal.pbio.3002427. Epub ahead of print. PMID: 38079451.
  • Hussaini S, Lädke SL, Schröder-Schetelig J, Venkatesan V, Quiñonez Uribe RA, Richter C, Majumder R, Luther S. Dissolution of spiral wave's core using cardiac optogenetics. PLoS Comput Biol. 2023 Dec 7;19(12):e1011660. doi: 10.1371/journal.pcbi.1011660. Epub ahead of print. PMID: 38060618.
  • Torkzadeh T, Asadi Z, Jafari Atrabi M, Eivazkhani F, Khodadi M, Hajiaghalou S, Akbarinejad V, Fathi R. Optimisation of hormonal treatment to improve follicular development in one-day-old mice ovaries cultured under in vitro condition. Reprod Fertil Dev. 2023 Nov;35(18):733-749. doi: 10.1071/RD23027 . PMID: 37995332.
  • Sounart H, Lázár E, Masarapu Y, Wu J, Várkonyi T, Glasz T, Kiss A, Borgström E, Hill A, Rezene S, Gupta S, Jurek A, Niesnerová A, Druid H, Bergmann O, Giacomello S. Dual spatially resolved transcriptomics for human host-pathogen colocalization studies in FFPE tissue sections. Genome Biol. 2023 Oct 19;24(1):237. doi: 10.1186/s13059-023-03080-y . PMID: 37858234; PMCID: PMC10588020.
  • Roeder SS, Bonnin EA, Wu TD, Guerquin-Kern JL, Jabari S, Brandner S, Eyüpoglu IY, Gollwitzer S, Hamer HM, Gerner ST, Döppner TR, Rummel C, Englund E, Heimke-Brinck R, Borst T, Daniel C, Amann K, Schlötzer-Schrehardt U, Tonchev AB, Roessler K, Schwab S, Bergmann O, Rizzoli SO, Huttner HB. Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry. Front Neurosci. 2023 Oct 5;17:1274607. doi: 10.3389/fnins.2023.1274607. PMID: 37869505; PMCID: PMC10585107.
  • Datseris G, Kottlarz I, Braun AP, Parlitz U. Estimating fractal dimensions: A comparative review and open source implementations. Chaos. 2023 Oct 1;33(10):102101. doi: 10.1063/5.0160394 . PMID: 37831803.
  • Goodarzi Hosseinabadi H, Biswas A, Bhusal A, Yousefinejad A, Lall A, Zimmermann WH, Miri AK, Ionov L. 4D-Printable Photocrosslinkable Polyurethane-Based Inks for Tissue Scaffold and Actuator Applications. Small. 2023 Sep 28:e2306387. doi: 10.1002/smll.202306387. Epub ahead of print. PMID: 37771189.
  • Sayour NV, Tóth VÉ, Nagy RN, Vörös I, Gergely TG, Onódi Z, Nagy N, Bödör C, Váradi B, Ruppert M, Radovits T, Bleckwedel F, Zelarayán LC, Pacher P, Ágg B, Görbe A, Ferdinandy P, Varga ZV. Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction. Int J Mol Sci. 2023 Sep 7;24(18):13826. doi: 10.3390/ijms241813826. PMID: 37762130; PMCID: PMC10531061.
  • Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A,Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Díaz I Pedrosa N, Rapedius M, Döring Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Brügmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann WH, Voigt N. Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development. Cardiovasc Res. 2023 Sep 7:cvad143. doi: 10.1093/cvr/cvad143. Epub ahead of print. PMID: 37677054.
  • Mustroph J, Baier MJ, Unsin D, Provaznik Z, Kozakov K, Lebek S, Tarnowski D, Schildt S, Voigt N, Wagner S, Maier LS, Neef S. Ethanol-Induced Atrial Fibrillation Results From Late INa and Can Be Prevented by Ranolazine. Circulation. 2023 Aug 22;148(8):698-700. doi: 10.1161/CIRCULATIONAHA.123.064561. Epub 2023 Aug 21. PMID: 37603603.
  • Aron M, Lilienkamp T, Luther S, Parlitz U. Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm. Front Netw Physiol. 2023 Jul 24;3:1172454. doi: 10.3389/fnetp.2023.1172454. PMID: 37555132; PMCID: PMC10406519.
  • Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A. An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes. Circ Res. 2023 Jul 7;133(2):e19-e46. doi: 10.1161/CIRCRESAHA.122.321157 . Epub 2023 Jun 14. PMID: 37313752.
  • Voigt N, Seibertz F, Fakuade FE. Vicious Twins: RyR2 Dysfunction and Structural Remodeling. Circ Res. 2023 Jul 7;133(2):193-195. doi: 10.1161/CIRCRESAHA.123.323144. Epub 2023 Jul 6. PMID: 37410856.
  • Priesmeier L, Schoger E, Cyganek L, Cecilia Zelarayán L. Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC). Stem Cell Res. 2023 Jul 5;71:103163. doi: 10.1016/j.scr.2023.103163. Epub ahead of print. PMID: 37433260.
  • Rashidi A, Alizadeh A, Sharifi SD, Najafi A. The histopathological changes of liver and testis of Japanese quail chicks fed different levels of dietary L-valine. Vet Anim Sci. 2023 Jul 4;21:100302. doi: 10.1016/j.vas.2023.100302 . PMID: 37497117; PMCID: PMC10365950.
  • Emami N, Alizadeh A, Maleki-Hajiagha A, Dizavi A, Vesali S, Moini A. Serum and follicular fluid levels of soluble receptor for advanced glycation end-products in women with and without polycystic ovary syndrome. J Ovarian Res. 2023 Jun 30;16(1):127. doi: 10.1186/s13048-023-01224-z . PMID: 37391740; PMCID: PMC10311803.
  • Ghadikolaei PY, Ghaleno LR, Vesali S, Janzamin E, Gilani MAS, Sajadi H, Dizaj AVT, Shahverdi A, Drevet JR, Alizadeh A. Epidemiology of sperm DNA fragmentation in a retrospective cohort of 1,191 men. Andrology. 2023 Jun 6. doi: 10.1111/andr.13472. Epub ahead of print. PMID: 37280171.
  • Kottlarz I, Parlitz U. Ordinal pattern-based complexity analysis of high-dimensional chaotic time series. Chaos. 2023 May 1;33(5):053105. doi: 10.1063/5.0147219. PMID: 37133925.
  • Lerchenmüller C, Zelarayan L, Streckfuss-Bömeke K, Gimenez MR, Schnabel R, Hashemi D, Baldus S, Rudolph TK, Morbach C. Moving toward gender equity in the cardiology and cardiovascular research workforce in Germany: a report from the German Cardiac Society. Eur Heart J Open. 2023 Mar 29;3(2):oead034. doi: 10.1093/ehjopen/oead034. PMID: 37090057; PMCID: PMC10114529.
  • Seibertz F, Sutanto H, Dülk R, Pronto JRD, Springer R, Rapedius M, Liutkute A, Ritter M, Jung P, Stelzer L, Hüsgen LM, Klopp M, Rubio T, Fakuade FE, Mason FE, Hartmann N, Pabel S, Streckfuss-Bömeke K, Cyganek L, Sossalla S, Heijman J, Voigt N. Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes. Basic Res Cardiol. 2023 Apr 5;118(1):14. doi: 10.1007/s00395-022-00973-0. PMID: 37020075.
  • Hoffmann J, Hanß S, Kraus M, Schaller J, Schäfer C, Stahl D, Anker SD, Anton G, Bahls T, Blankenberg S, Blumentritt A, Boldt LH, Cordes S, Desch S, Doehner W, Dörr M, Edelmann F, Eitel I, Endres M, Engelhardt S, Erdmann J, Eulenburg K, Falk V, Felix SB, Frank D, Franke T, Frey N, Friede T, Geidel L, Germans L, Grabmaier U, Halle M, Hausleiter J, Jakobi V, Jebran AF, Jobs A, Kääb S, Karakas M, Katus HA, Klatt A, Knosalla C, Krebser J, Landmesser U, Lee M, Lehnert K, Lesser S, Leyh K, Lorbeer R, Mach-Kolb S, Meder B, Nagel E, Nolte CH, Parwani AS, Petersmann A, Puls M, Rau H, Reiser M, Rienhoff O, Scharfe T, Schattschneider M, Scheel H, Schnabel RB, Schuster A, Schmitt B, Seidler T, Seiffert M, Stähli BE, Stas A, J Stocker T, von Stülpnagel L, Thiele H, Wachter R, Wakili R, Weis T, Weitmann K, Wichmann HE, Wild P, Zeller T, Hoffmann W, Zeisberg EM, Zimmermann WH, Krefting D, Kühne T, Peters A, Hasenfuß G, Massberg S, Sommer T, Dimmeler S, Eschenhagen T, Nauck M. The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies. Clin Res Cardiol. 2023 Mar 8. doi: 10.1007/s00392-023-02177-5. Epub ahead of print. PMID: 36884078.
  • Grammatika Pavlidou N, Dobrev S, Beneke K, Reinhardt F, Pecha S, Jacquet E, Abu-Taha IH, Schmidt C, Voigt N, Kamler M, Schnabel RB, Baczkó I, Garnier A, Reichenspurner H, Nikolaev VO, Dobrev D, Molina CE. Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism. Eur Heart J. 2023 Feb 22:ehad086. doi: 10.1093/eurheartj/ehad086. Epub ahead of print. PMID: 36810794.
  • Hauke L, Primeßnig A, Eltzner B, Radwitz J, Huckemann SF, Rehfeldt F. FilamentSensor 2.0: An open-source modular toolbox for 2D/3D cytoskeletal filament tracking. PLoS One. 2023 Feb 6;18(2):e0279336. doi: 10.1371/journal.pone.0279336. PMID: 36745610; PMCID: PMC9901806.
  • Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC. Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling. Commun Biol. 2023 Jan 21;6(1):79. doi: 10.1038/s42003-022-04402-9. PMID: 36681760; PMCID: PMC9867722.
  • Steyer J, Lilienkamp T, Luther S, Parlitz U. The role of pulse timing in cardiac defibrillation. Front Netw Physiol. 2023 Jan 4;2:1007585. doi: 10.3389/fnetp.2022.1007585. PMID: 36926106; PMCID: PMC10013017.

2022

  • Voigt N, Maack C, Pronto JRD. Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation. J Am Coll Cardiol. 2022 Dec 6;80(23):2220-2223. doi: 10.1016/j.jacc.2022.09.043. PMID: 36456052.
  • Moradi M, Zhandi M, Sharafi M, Akbari A, Atrabi MJ, Totonchi M. Gene expression profile of placentomes and clinical parameters in the cows with retained placenta. BMC Genomics. 2022 Nov 21;23(1):760. doi: 10.1186/s12864-022-08989-5. PMID: 36411408; PMCID: PMC9677913.
  • Schmidt J, Dreha-Kulaczewski S, Zafeiriou MP, Schreiber MK, Wilken B, Funke R, Neuhofer CM, Altmüller J, Thiele H, Nürnberg P, Biskup S, Li Y, Zimmermann WH, Kaulfuß S, Yigit G, Wollnik B. Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum. Front Cell Dev Biol. 2022 Nov 16;10:1025332. doi: 10.3389/fcell.2022.1025332. PMID: 36467423; PMCID: PMC9710855.
  • Shahriyari M, Islam MR, Sakib SM, Rinn M, Rika A, Krüger D, Kaurani L, Gisa V, Winterhoff M, Anandakumar H, Shomroni O, Schmidt M, Salinas G, Unger A, Linke WA, Zschüntzsch J, Schmidt J, Bassel-Duby R, Olson EN, Fischer A, Zimmermann WH, Tiburcy M. Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy. J Cachexia Sarcopenia Muscle. 2022 Dec;13(6):3106-3121. doi: 10.1002/jcsm.13094. Epub ahead of print. PMID: 36254806.
  • Haertter D, Wang X, Fogerson SM, Ramkumar N, Crawford JM, Poss KD, Di Talia S, Kiehart DP, Schmidt CF. DeepProjection: Specific and robust projection of curved 2D tissue sheets from 3D microscopy using deep learning. Development. 2022 Sep 30:dev.200621. doi: 10.1242/dev.200621. Epub ahead of print. PMID: 36178108.
  • Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, Becker N, Majumder R, Clauß S, Fertig N, Voigt N. A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes. Commun Biol. 2022 Sep 15;5(1):969. doi: 10.1038/s42003-022-03871-2. PMID: 36109584; PMCID: PMC9477872.
  • Rapedius M, Obergrussberger A, Humphries ESA, Scholz S, Rinke-Weiss I, Goetze TA, Brinkwirth N, Rotordam MG, Strassmaier T, Randolph A, Friis S, Liutkute A, Seibertz F, Voigt N, Fertig N. There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments. Front. Mol. Neurosci. 15, 2022. doi: 10.3389/fnmol.2022.982316.
  • Santos GL, DeGrave AN, Rehman A, Al Disi S, Xhaxho K, Schröder H, Bao G, Meyer T, Tiburcy M, Dworatzek E, Zimmermann WH, Lutz S. Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues. Biomater Adv. 2022 Aug;139:213041. doi: 10.1016/j.bioadv.2022.213041. Epub 2022 Jul 21. PMID: 35909053.
  • Lilienkamp T, Parlitz U, Luther S. Non-monotonous dose response function of the termination of spiral wave chaos. Sci Rep. 2022 Jul 14;12(1):12043. doi: 10.1038/s41598-022-16068-8. PMID: 35835979; PMCID: PMC9283470.
  • Rosholm KR, Badone B, Karatsiompani S, Nagy D, Seibertz F, Voigt N, Bell DC. Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp. Front Mol Neurosci. 2022 Jun 22;15:898717. doi: 10.3389/fnmol.2022.898717. PMID: 35813069; PMCID: PMC9258620.
  • Zimmermann WH. Remote control of the heart and beyond. Science. 2022 May 27;376(6596):917-918. doi: 10.1126/science.abq0605. Epub 2022 May 26. PMID: 35617399.
  • Tiburcy M, Meyer T, Satin PL, Zimmermann WH. Defined Engineered Human Myocardium for Disease Modeling, Drug Screening, and Heart Repair. Methods Mol Biol. 2022;2485:213-225. doi: 10.1007/978-1-0716-2261-2_14. PMID: 35618908.
  • Jung P, Seibertz F, Fakuade FE, Ignatyeva N, Sampathkumar S, Ritter M, Li H, Mason FE, Ebert A, Voigt N. Increased cytosolic calcium buffering contributes to a cellular arrhythmogenic substrate in iPSC-cardiomyocytes from patients with dilated cardiomyopathy. Basic Res Cardiol. 2022 May 2;117(1):5. doi: 10.1007/s00395-022-00912-z. PMID: 35499658.
  • Fakuade FE, Fauconnier J, Voigt N. Background calcium influx in arrhythmia: lead actor or extra? J Physiol. 2022 Apr 21. doi: 10.1113/JP283032. Epub ahead of print. PMID: 35451079.
  • Germena G, Zelarayán LC, Hinkel R. Cellular Chitchatting: Exploring the Role of Exosomes as Cardiovascular Risk Factors. Front Cell Dev Biol. 2022 Mar 31;10:860005. doi: 10.3389/fcell.2022.860005. PMID: 35433670; PMCID: PMC9008366.
  • Zschüntzsch J, Meyer S, Shahriyari M, Kummer K, Schmidt M, Kummer S, Tiburcy M. The Evolution of Complex Muscle Cell In Vitro Models to Study Pathomechanisms and Drug Development of Neuromuscular Disease. Cells. 2022 Apr 5;11(7):1233. doi: 10.3390/cells11071233. PMID: 35406795; PMCID: PMC8997482.
  • Jebran AF, Tiburcy M, Biermann D, Balfanz P, Didié M, Karikkineth BC, Schöndube F, Kutschka I, Zimmermann WH. Transmural myocardial repair with engineered heart muscle in a rat model of heterotopic heart transplantation - A proof-of-concept study. J Mol Cell Cardiol. 2022 Apr 4;168:3-12. doi: 10.1016/j.yjmcc.2022.03.013. Epub ahead of print. PMID: 35390437.
  • Liutkute A, Brundel BJ, Voigt N. Not the classical serendipity: does doxapram treat atrial fibrillation? Cardiovasc Res. 2022 Apr 15:cvac044. doi: 10.1093/cvr/cvac044. Epub ahead of print. PMID: 35425974.
  • Latif MU, Schmidt GE, Mercan S, Rahman R, Gibhardt CS, Stejerean-Todoran I, Reutlinger K, Hessmann E, Singh SK, Moeed A, Rehman A, Butt UJ, Bohnenberger H, Stroebel P, Bremer SC, Neesse A, Bogeski I, Ellenrieder V. NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression. Gut. 2022 Apr 1:gutjnl-2021-325013. doi: 10.1136/gutjnl-2021-325013. Epub ahead of print. PMID: 35365570.
  • Peris-Yagüe V, Rubio T, Fakuade FE, Voigt N, Luther S, Majumder R. A Mathematical Model for Electrical Activity in Pig Atrial Tissue. Front Physiol. 2022 Mar 10;13:812535. doi: 10.3389/fphys.2022.812535. PMID: 35360247; PMCID: PMC8960738.
  • Dewenter M, Pan J, Knödler L, Tzschöckel N, Henrich J, Cordero J, Dobreva G, Lutz S, Backs J, Wieland T, Vettel C. Chronic isoprenaline/phenylephrine vs. exclusive isoprenaline stimulation in mice: critical contribution of alpha1-adrenoceptors to early cardiac stress responses. Basic Res Cardiol. 2022 Mar 14;117(1):15. doi: 10.1007/s00395-022-00920-z. PMID: 35286475; PMCID: PMC8921177.
  • Haupt LP, Rebs S, Maurer W, Hübscher D, Tiburcy M, Pabel S, Maus A, Köhne S, Tappu R, Haas J, Li Y, Sasse A, Santos CCX, Dressel R, Wojnowski L, Bunt G, Möbius W, Shah AM, Meder B, Wollnik B, Sossalla S, Hasenfuss G, Streckfuss-Bömeke K. Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients. Basic Res Cardiol. 2022 Mar 8;117(1):13. doi: 10.1007/s00395-022-00918-7. PMID: 35260914; PMCID: PMC8904375.
  • Shomroni O, Sitte M, Schmidt J, Parbin S, Ludewig F, Yigit G, Zelarayan LC, Streckfuss-Bömeke K, Wollnik B, Salinas G. A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease. Sci Rep. 2022 Mar 8;12(1):4091. doi: 10.1038/s41598-022-07874-1. PMID: 35260714; PMCID: PMC8904555.
  • Levay MK, Krobert KA, Vogt A, Ahmad A, Jungmann A, Neuber C, Pasch S, Hansen A, Müller OJ, Lutz S, Wieland T. RGS3L allows for an M2 muscarinic receptor-mediated RhoA-dependent inotropy in cardiomyocytes. Basic Res Cardiol. 2022 Mar 1;117(1):8. doi: 10.1007/s00395-022-00915-w. PMID: 35230541; PMCID: PMC8888479.
  • Khodadi M, Atrabi MJ, Torkzadeh T, Fazli M, Akbarinejad V, Fathi R. High steroid content in conditioned medium of granulosa cells may disrupt primordial follicles formation in in vitro cultured one-day-old murine ovaries. Reprod Biol. 2022 Mar;22(1):100613. doi: 10.1016/j.repbio.2022.100613. Epub 2022 Feb 14. PMID: 35176681.
  • Söldner R, Rheinländer S, Meyer T, Olszowy M, Austerjost J. Human-Device Interaction in the Life Science Laboratory. Adv Biochem Eng Biotechnol. 2022 Jan 29. doi: 10.1007/10_2021_183. Epub ahead of print. PMID: 35091814.
  • Schoger E, Lelek S, Panáková D, Zelarayán LC. Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine. Front Cardiovasc Med. 2022 Jan 14;8:783072. doi: 10.3389/fcvm.2021.783072. PMID: 35097003; PMCID: PMC8795974.
  • Brandenburg S, Pawlowitz J, Steckmeister V, Subramanian H, Uhlenkamp D, Scardigli M, Mushtaq M, Amlaz SI, Kohl T, Wegener JW, Arvanitis DA, Sanoudou D, Sacconi L, Hasenfuß G, Voigt N, Nikolaev VO, Lehnart SE. A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes. J Mol Cell Cardiol. 2022 Jan 13;165:141-157. doi: 10.1016/j.yjmcc.2022.01.003. PMID: 35033544.

2021

  • Zelarayan L, Vendrell V, Domínguez-Frutos E, López-Hernández I, Schimmang-Alonso K, Alonso MT, Alvarez Y, Maier H, Anderson MJ, Lewandoski M, Schimmang T. Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival. Dev Dyn. 2021 Oct 31. doi: 10.1002/dvdy.435. Epub ahead of print. PMID: 34719815.
  • Dankovich TM, Kaushik R, Olsthoorn LHM, Petersen GC, Giro PE, Kluever V, Agüi-Gonzalez P, Grewe K, Bao G, Beuermann S, Hadi HA, Doeren J, Klöppner S, Cooper BH, Dityatev A, Rizzoli SO. Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R. Nat Commun. 2021 Dec 8;12(1):7129. doi: 10.1038/s41467-021-27462-7. PMID: 34880248; PMCID: PMC8654841.
  • Zhang J, Bolli R, Garry DJ, Marbán E, Menasché P, Zimmermann WH, Kamp TJ, Wu JC, Dzau VJ. Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Nov 23;78(21):2092-2105. doi: 10.1016/j.jacc.2021.09.019. PMID: 34794691.
  • Zheng X, Zhang L, Kuang Y, Venkataramani V, Jin F, Hein K, Zafeiriou MP, Lenz C, Moebius W, Kilic E, Hermann DM, Weber MS, Urlaub H, Zimmermann WH, Bähr M, Doeppner TR. Correction to: Extracellular Vesicles Derived from Neural Progenitor Cells--a Preclinical Evaluation for Stroke Treatment in Mice. Transl Stroke Res. 2021 Nov 9. doi: 10.1007/s12975-021-00961-x. Epub ahead of print. Erratum for: Transl Stroke Res. 2021 Feb;12(1):185-203. PMID: 34751929.
  • Fomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, Folsche L, Hobbach AJ, von Frieling-Salewsky M, Unger A, Hucke A, Koser F, Kassner A, Sielemann K, Streckfuß-Bömeke K, Hasenfuss G, Goedel A, Laugwitz KL, Moretti A, Gummert JF, Dos Remedios CG, Reinecke H, Knöll R, van Heesch S, Hubner N, Zimmermann WH, Milting H, Linke WA. Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations. Sci Transl Med. 2021 Nov 3;13(618):eabd3079. doi: 10.1126/scitranslmed.abd3079. Epub 2021 Nov 3. PMID: 34731013.
  • Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimoglu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka MT, Janowitz D, Kilimann I, Kleinedam L, Laske C, Metzger CD, Munk MH, Perneczky R, Peters O, Priller J, Rauchmann BS, Roy N, Schneider A, Spottke A, Spruth EJ, Teipel S, Tscheuschler M, Wagner M, Wiltfang J, Düzel E, Jessen F; Delcode Study Group, Rizzoli SO, Zimmermann WH, Schulze TG, Falkai P, Sananbenesi F, Fischer A. A microRNA signature that correlates with cognition and is a target against cognitive decline. EMBO Mol Med. 2021 Nov 8;13(11):e13659. doi: 10.15252/emmm.202013659. Epub 2021 Oct 11. PMID: 34633146; PMCID: PMC8573587.
  • Pikunov A.V., Syunyaev R.A., Steckmeister V., Kutschka I., Voigt N., Efimov I.R. (2021) Personalization of Mathematical Models of Human Atrial Action Potential. In: Favorskaya M.N., Favorskaya A.V., Petrov I.B., Jain L.C. (eds) Smart Modelling For Engineering Systems. Smart Innovation, Systems and Technologies, vol 214. Springer, Singapore. https://doi.org/10.1007/978-981-33-4709-0_19.
  • Shahriyari M, Islam MR, Sakib MS, Rika A, Krüger D, Kaurani L, Anandakumar H, Shomroni O, Schmidt M, Salinas G, Unger A, Linke WA, Zschüntzsch J, Schmidt J, André Fischer, Zimmermann WH, Tiburcy M. Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity, bioRxiv 2021.07.12.452030; doi: https://doi.org/10.1101/2021.07.12.452030.
  • Diaz-Maue L, Steinebach J, Schwaerzle M, Luther S., Ruther P, Richter C. Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts. Journal of Visualized Experiments : Jove. 2021 Aug(174). DOI: 10.3791/62335. PMID: 34515679.
  • Kusch H, Kossen R, Suhr M, Freckmann L, Weber L, Henke C, Lehmann C, Rheinländer S, Aschenbrandt G, Kühlborn LK, Marzec B, Menzel J, Schwappach B, Zelarayán LC, Cyganek L, Antonios G, Kohl T, Lehnart SE, Zoremba M, Sax U, Nussbeck SY. Management of Metadata Types in Basic Cardiological Research. Stud Health Technol Inform. 2021 Sep 21;283:59-68. doi: 10.3233/SHTI210542. PMID: 34545820.
  • Chen Y, Lüttmann FF, Schoger E, Schöler HR, Zelarayán LC, Kim KP, Haigh JJ, Kim J, Braun T. Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. Science. 2021 Sep 24;373(6562):1537-1540. doi: 10.1126/science.abg5159. Epub 2021 Sep 23. PMID: 34554778.
  • Brittan M, Zimmermann WH. Cell programming to protect the ischemic heart and limb. Mol Ther. 2021 Oct 6;29(10):2894-2895. doi: 10.1016/j.ymthe.2021.09.007. Epub 2021 Sep 23. PMID: 34555312; PMCID: PMC8551401.
  • Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC. Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation. Stem Cell Res. 2021 Aug 26;56:102518. doi: 10.1016/j.scr.2021.102518. Epub ahead of print. PMID: 34481190.
  • Santos GL, Meyer T, Tiburcy M, DeGrave A, Zimmermann WH, Lutz S. Fibroblast Derived Human Engineered Connective Tissue for Screening Applications. J Vis Exp. 2021 Aug 20;(174). doi: 10.3791/62700.
  • Dai Y, Amenov A, Ignatyeva N, Koschinski A, Xu H, Robra F, Tiburcy M, Linke WA, Zaccolo M, Hasenfuss G, Zimmermann WH, Ebert A. Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients. Sci Rep. 2020 10 (1), 209 2020 Jan 14. PubMed PMID: 31937807.
  • Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC. Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression. Stem Cell Res. 2021 Jul 27;55:102473. doi: 10.1016/j.scr.2021.102473. Epub ahead of print. PMID: 34343828.
  • Zheng X, Zhang L, Kuang Y, Venkataramani V, Jin F, Hein K, Zafeiriou MP, Lenz C, Moebius W, Kilic E, Hermann DM, Weber MS, Urlaub H, Zimmermann WH, Bähr M, Doeppner TR. Extracellular Vesicles Derived from Neural Progenitor Cells--a Preclinical Evaluation for Stroke Treatment in Mice. Transl Stroke Res. 2021 Feb;12(1):185-203. doi: 10.1007/s12975-020-00814-z. Epub 2020 May 2. PMID: 32361827; PMCID: PMC7803677..
  • Zimmermann WH. Editorial commentary: Challenges to heart repair with pluripotent stem cell-derived cardiomyocytes. Trends Cardiovasc Med. 2021 Feb;31(2):91-92. doi: 10.1016/j.tcm.2020.03.006. Epub 2020 Apr 8. PMID: 32276084.
  • Weber P, Baltus D, Jatho A, Drews O, Zelarayan LC, Wieland T, Lutz S. RhoGEF17-An Essential Regulator of Endothelial Cell Death and Growth. Cells. 2021 Mar 27;10(4):741. doi: 10.3390/cells10040741. PMID: 33801779; PMCID: PMC8067313.
  • Kittana N, Assali M, Zimmermann WH, Liaw N, Santos GL, Rehman A, Lutz S. Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes. Int J Nanomedicine. 2021 Feb 15;16:989-1000. doi: 10.2147/IJN.S289107. PMID:33633447; PMCID: PMC7901244..
  • Wrobel C, Zafeiriou MP, Moser T. Understanding and treating paediatric hearing impairment. EBioMedicine. 2021 Jan;63:103171. doi: 10.1016/j.ebiom.2020.103171. Epub 2021 Jan 7. PMID: 33422987; PMCID: PMC7808910.
  • Zimmermann WH. Organs-on-chip models for cardiovascular drug development. Cardiovasc Res. 2021 Aug 4:cvab229. doi: 10.1093/cvr/cvab229. Epub ahead of print. PMID: 34347045.
  • Raad F, Khan TA, Esser TU, Hudson JE, Seth BI, Fujita B, Gandamala R, Tietze LF, Zimmermann WH. Chalcone Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering. ChemMedChem. 2021 Jul 26. doi: 10.1002/cmdc.202100222. Epub ahead of print. PMID: 34309224.
  • Moussavi A, Mißbach S, Serrano Ferrel C, Ghasemipour H, Kötz K, Drummer C, Behr R, Zimmermann WH, Boretius S. Comparison of cine and real-time cardiac MRI in rhesus macaques. Sci Rep. 2021 May 21;11(1):10713. doi: 10.1038/s41598-021-90106-9. PMID: 34021218; PMCID: PMC8140156.
  • Villa Del Campo C, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR. Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer. Cardiovasc Res. 2021 Feb 18:cvab054. doi: 10.1093/cvr/cvab054. Epub ahead of print. PMID: 33599250.
  • Kottlarz I, Berg S, Toscano-Tejeida D, Steinmann I, Bähr M, Luther S, Wilke M, Parlitz U, Schlemmer A. Extracting Robust Biomarkers From Multichannel EEG Time Series Using Nonlinear Dimensionality Reduction Applied to Ordinal Pattern Statistics and Spectral Quantities. Front Physiol. 2021 Feb 1;11:614565. doi: 10.3389/fphys.2020.614565. PMID: 33597891; PMCID: PMC7882607.
  • Kyryachenko S, Georges A, Yu M, Barrandou T, Guo L, Bruneval P, Rubio T, Gronwald J, Baraki H, Kutschka I, Aras KK, Efimov IR, Norris RA, Voigt N, Bouatia-Naji N. Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021 Mar 5;128(5):e84-e101. doi: 10.1161/CIRCRESAHA.120.317581. Epub 2021 Jan 28. PMID: 33508947; PMCID: PMC8316483.
  • Peper J, Kownatzki-Danger D, Weninger G, Seibertz F, Pronto JRD, Sutanto H, Pacheu-Grau D, Hindmarsh R, Brandenburg S, Kohl T, Hasenfuss G, Gotthardt M, Rog-Zielinska EA, Wollnik B, Rehling P, Urlaub H, Wegener J, Heijman J, Voigt N, Cyganek L, Lenz C, Lehnart SE. Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Circ Res. 2021 Mar 19;128(6):e102-e120. doi: 10.1161/CIRCRESAHA.119.316547. Epub 2021 Jan 25. PMID: 33486968.
  • Trosclair K, Si M, Watts M, Gautier NM, Voigt N, Traylor J, Bitay M, Baczko I, Dobrev D, Hamilton KA, Bhuiyan MS, Dominic P, Glasscock E. Kv1.1 potassium channel subunit deficiency alters ventricular arrhythmia susceptibility, contractility, and repolarization. Physiol Rep. 2021 Jan;9(1):e14702. doi: 10.14814/phy2.14702. PMID: 33427415; PMCID: PMC7798052.
  • Zimmermann WH. Multiscale Strategy to Resolve Stroma-Cardiac Fibroblast Interactions. Circ Res. 2021 Jan 8;128(1):39-41. doi: 10.1161/CIRCRESAHA.120.318494. Epub 2021 Jan 7. PMID: 33411630.
  • Fakuade FE, Tomsits P, Voigt N. Connexin hemichannels in atrial fibrillation: orphaned and irrelevant? Cardiovasc Res. 2021 Jan 1;117(1):4-6. doi: 10.1093/cvr/cvaa308. PMID: 33112373.

2020

  • Cavero I, Seimetz D, Koziel D, Zimmermann WH, Holzgrefe HH (2020) 19th Annual Meeting of the Safety Pharmacology Society: regulatory and safety perspectives for advanced therapy medicinal products (cellular and gene therapy products). EXPERT OPIN DRUG SAF 19(5): 553-558, doi: 10.1080/14740338.2020.1741546
  • Dai Y, Amenov A, Ignatyeva N, Koschinski A, Xu H, Soong PL, Tiburcy M, Linke WA, Zaccolo M, Hasenfuss G, Zimmermann WH, Ebert A. Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients. Sci Rep. 2020 10 (1), 209 2020 Jan 14. PubMed PMID: 31937807.
  • Schoger E, Carroll KJ, Iyer LM, McAnally JR, Tan W, Liu N, Noack C, Shomroni O, Salinas G, Groß J, Herzog N, Doroudgar S, Bassel-Duby R, Zimmermann WH, Zelarayán LC. CRISPR-mediated activation of endogenous gene expression in the postnatal heart. Circ Res. 2020 10.1161/CIRCRESAHA.118.314522. PubMed PMID: 31730408.
  • Fakuade FE, Steckmeister V, Seibertz F, Gronwald J, Kestel S, Menzel J, Pronto JRD, Taha K, Haghighi F, Kensah G, Pearman CM, Wiedmann F, Teske AJ, Schmidt C, Dibb KM, El-Essawi A, Danner BC, Baraki H, Schwappach B, Kutschka I, Mason FE, Voigt N (2020) Altered Atrial Cytosolic Calcium Handling Contributes to the Development of Postoperative Atrial Fibrillation. CARDIOVASC RES 32: 43-48, doi: 10.1093/cvr/cvaa162
  • Foo R, Wang Y, Zimmermann WH, Backs J, Wang DW (2020) Cardiovascular molecular mechanisms of disease with COVID-19. J MOL CELL CARDIOL 141: 107, doi: 0.1016/j.yjmcc.2020.04.010
  • Grigorian-Shamagian L, Sanz-Ruiz R, Climent A, Badimon L, Barile L, Bolli R, Chamuleau S, Grobbee DE, Janssens S, Kastrup J, Kragten-Tabatabaie L, Madonna R, Mathur A, Menasché P, Pompilio G, Prosper F, Sena E, Smart N, Zimmermann WH, Fernández-Avilés F. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine. Cardiovasc Res. 2021 May 25;117(6):1428-1433. doi: 10.1093/cvr/cvaa337. PMID: 33258961
  • Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L (2020) Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy. CIRCULATION 142(11): 1059-1076, doi: 10.1161/CIRCULATIONAHA.119.044794
  • Hofhuis J, Bersch K, Wagner S, Molina C, Fakuade FE, Iyer LM, Streckfuss-Bömeke K, Toischer K, Zelarayán LC, Voigt N, Nikolaev VO, Maier LS, Klinge L, Thoms S (2020) Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system. EUROPACE 22(7): 1119-1131, doi: 10.1093/europace/euaa093
  • Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J (2020) High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts. FRONT PHYSIOL 11: 464, doi: 10.3389/fphys.2020.00464
  • Khadjeh S, Hindmarsh V, Weber F, Cyganek L, Vidal RO, Torkieh S, Streckfuss-Bömeke K, Lbik D, Tiburcy M, Mohamed BA, Bonn S, Toischer K, Hasenfuss G (2020) CRISPLD1: a novel conserved target in the transition to human heart failure. BASIC RES CARDIOL 115(3): 27, doi: 10.1007/s00395-020-0784-4
  • Kottlarz I, Berg S, Toscano-Tejeida D, Steinmann I, Bähr M, Luther S, Wilke M, Parlitz U, Schlemmer A (2020) Extracting Robust Biomarkers From Multichannel EEG Time Series Using Nonlinear Dimensionality Reduction Applied to Ordinal Pattern Statistics and Spectral Quantities. FRONT PHYSIOL 11: 614565, doi: 10.3389/fphys.2020.614565
  • Levent E, Noack C, Zelarayán LC, Katschinski DM, Zimmermann WH, Tiburcy M (2020) Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium. CIRCULATION 142(17): 1694-1696, doi: 10.1161/CIRCULATIONAHA.119.044471
  • Maksymiak R, Ritchie E, Zimmermann WH, Maliko N, van der Werve M, Verschure M, Hoencamp R (2020) Historic cohort: outcome of chronic exertional compartment syndrome-suspected patients. BMJ Mil Health -: -, doi: 10.1136/jramc-2019-001290
  • Mason FE, Pronto JRD, Alhussini K, Maack C, Voigt N (2020) Cellular and mitochondrial mechanisms of atrial fibrillation. BASIC RES CARDIOL 115(6): 72, doi: 10.1007/s00395-020-00827-7
  • Montiel V, Bella R, Michel LYM, Esfahani H, De Mulder D, Robinson EL, Deglasse JP, Tiburcy M, Chow PH, Jonas JC, Gilon P, Steinhorn B, Michel T, Beauloye C, Bertrand L, Farah C, Dei Zotti F, Debaix H, Bouzin C, Brusa D, Horman S, Vanoverschelde JL, Bergmann O, Gilis D, Rooman M, Ghigo A, Geninatti-Crich S, Yool A, Zimmermann WH, Roderick HL, Devuyst O, Balligand JL (2020) Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide. SCI TRANSL MED 12(564): -, doi: 0.1126/scitranslmed.aay2176
  • Rathjens FS, Blenkle A, Iyer LM, Renger A, Syeda F, Noack C, Jungmann A, Dewenter M, Toischer K, El-Armouche A, Müller OJ, Fabritz L, Zimmermann WH, Zelarayan LC, Zafeiriou MP (2020) Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control. CARDIOVASC RES -: -, doi: 10.1093/cvr/cvaa239
  • Schmidt C, Voigt N (2020) Insights into cardiovascular research in Göttingen and Heidelberg: a report by the ESC Scientists of Tomorrow. CARDIOVASC RES 116(12): e162-e164, doi: 10.1093/cvr/cvaa165
  • Schoger E, Argyriou L, Zimmermann WH, Cyganek L, Zelarayán LC (2020) Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation. STEM CELL RES 48: 101944, doi: 10.1016/j.scr.2020.101944
  • Schoger E, Carroll KJ, Iyer LM, McAnally JR, Tan W, Liu N, Noack C, Shomroni O, Salinas G, Groß J, Herzog N, Doroudgar S, Bassel-Duby R, Zimmermann WH, Zelarayán LC (2020) CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart. CIRC RES 126(1): 6-24, doi: 10.1161/CIRCRESAHA.118.314522
  • Seibertz F, Reynolds M, Voigt N (2020) Single-Cell Optical Action Potential Measurement in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. JOVE-J VIS EXP -(166): -, doi: 10.3791/61890
  • Stauske M, Rodriguez Polo I, Haas W, Knorr DY, Borchert T, Streckfuss-Bömeke K, Dressel R, Bartels I, Tiburcy M, Zimmermann WH, Behr R (2020) Non-Human Primate iPSC Generation, Cultivation, and Cardiac Differentiation under Chemically Defined Conditions. CELLS-BASEL 9(6): -, doi: 10.3390/cells9061349
  • Tiburcy M, Meyer T, Liaw NY, Zimmermann WH (2020) Generation of Engineered Human Myocardium in a Multi-well Format. STAR Protoc 1(1): 100032, doi: 10.1016/j.xpro.2020.100032
  • Tomsits P, Schüttler D, Kääb S, Clauss S, Voigt N (2020) Isolation of High Quality Murine Atrial and Ventricular Myocytes for Simultaneous Measurements of Ca2+ Transients and L-Type Calcium Current. JOVE-J VIS EXP -(165): -, doi: 10.3791/61964
  • Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH (2020) Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. NAT COMMUN 11(1): 3791, doi: 10.1038/s41467-020-17521-w
  • Zimmermann WH (2020) Engineered Heart Muscle Models in Phenotypic Drug Screens. Handb Exp Pharmacol -: -, doi: 10.1007/164_2020_385
  • Zschüntzsch J, Jouvenal PV, Zhang Y, Klinker F, Tiburcy M, Liebetanz D, Malzahn D, Brinkmeier H, Schmidt J (2020) Long-term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy. J CACHEXIA SARCOPENI 11(4): 1018-1031, doi: 10.1002/jcsm.12569

2019

  • Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH. Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium. Front Physiol. 2019 Apr 4;10:272. doi: 10.3389/fphys.2019.00272. PMID: 31024328; PMCID: PMC6460052.
  • Schlick SF, Spreckelsen F, Tiburcy M, Iyer LM, Meyer T, Zelarayan LC, Luther S, Parlitz U, Zimmermann WH, Rehfeldt F. Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium. Prog Biophys Mol Biol. 2019 Jul;144:51-60. doi: 10.1016/j.pbiomolbio.2018.11.011. Epub 2018 Dec 12. PMID: 30553553.
  • Noack N*, Iyer LM*, Liaw NY, Schoger E, Khadjeh S, Wagner E, Woelfer M, Zafiriou MP, Milting H, Sossalla S, Streckfuss-Boemeke K, Hasenfuss G, Zimmermann WH, Zelarayán LC. KLF15-Wnt-dependent cardiac reprograming reveals a novel vascular player, SHISA3 in the mammalian heart. JACC. 2019 74(14):1804-1819. PubMed PMID: 31582141.
  • Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Yilmaz MB, Anker SD, Balligand J-L, Bauersachs J, Brutsaert D, Carrier L, Chlopicki S, Cleland JG, de Boer RA, Dietl A, Fischmeister R, Harjola V-P, Heymans S, Hilfiker-Kleiner D, Holzmeister J, de Keulenaer G, Limongelli G, Linke WA, Lund LH, Masip J, Metra M, Mueller C, Pieske B, Ponikowski P, Ristić A, Ruschitzka F, Seferović PM, Skouri H, Zimmermann WH, Mebazaa A. Treatments targeting inotropy. Eur Heart J. 2019, 40 (44), 3626-3644. PubMed PMID: 30295807.
  • El-Battrawy I, Müller J, Zhao Z, Cyganek L, Zhong R, Zhang F, Kleinsorge M, Lan H, Li X, Xu Q, Huang M, Liao Z, Moscu-Gregor A, Albers S, Dinkel H, Lang S, Diecke S, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou X, Akin I. Studying Brugada Syndrome with an SCN1B variants in human-induced pluripotent stem cell-derived cardiomyocytes. Front Cell Dev Biol. 2019, 7, 261. PubMed PMID: 31737628.
  • Burczyk MS, Burkhalter MD, Tena TC, Grisanti LA, Kauk M, Matysik S, Donow C, Kustermann M, Rothe M, Cui Y, Raad F, Laue S, Moretti A, Zimmermann WH, Wess J, Kühl M, Hoffmann C, Tilley DG, Philipp M. Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. JCI Insight. 2019, 4 (20). PubMed PMID: 31619590.
  • El-Battrawy I, Albers S, Cyganek L, Zhao Z, Lan H, Li X, Xu Q, Kleinsorge M, Huang M, Liao Z, Zhong R, Rudic B, Müller J, Dinkel H, Lang S, Diecke S, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou X, Akin I. A cellular model of Brugada Syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes. Europace. 2019, 21 (9), 1410-1421. PubMed PMID: 31106349.
  • Santos GL, Hartmann S, Zimmermann WH, Ridley A, Lutz S. Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues. J Mol Cell Cardiol. 2019, 134, 13-28. PubMed PMID: 31233754.
  • Suhr M, Umbach N, Meyer T, Zimmermann WH, Sax U. Cardiac tissue engineering as use case to connect biomedical research laboratories to an emerging global data infrastructure. Stud Health Technol Inform. 209, 264, 363-367. PubMed PMID: 31437946.
  • Frank D, Rangrez AY, Friedrich C, Dittmann S, Stallmeyer B, Yadav P, Bernt A, Schulze-Bahr E, Borlepawar A, Zimmermann WH, Peischard S, Seebohm G, Linke WA, Baba HA, Krüger M, Unger A, Usinger P, Frey N, Schulze-Bahr E. Cardiac α-Actin (ACTC1) Gene Mutation Causes Atrial-Septal Defects Associated With Late-Onset Dilated Cardiomyopathy. Circ Genom Precis Med. 2019, 12 (8), e002491. PubMed PMID: 31430208.
  • Zhao Z, Li X, El-Battrawy I, Lan H, Zhong R, Xu Q, Huang M, Liao Z, Lang S, Zimmermann WH, Cyganek L, Wieland T, Akin I, Zhou X-B, Borggrefe M. Drug Testing in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1. Clin Pharmacol Ther. 2019, 106 (3), 642-651. PubMed PMID: 30947366.
  • Goldfracht I, Efraim Y, Shinnawi R, Kovalev E, Huber I, Gepstein A, Arbel G, Shaheen N, Tiburcy M, Zimmermann WH, Machluf M, Gepstein L. Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications. Acta Biomater. 2019, 92, 145-159/ 2019 Jul 1. PubMed PMID: 31075518.
  • Tarantola M, Meyer T, Schmidt CF, Zimmermann WH. Physics meets medicine - at the heart of active matter. Prog Biophys Mol Biol. 2019, 144, 1-2. PubMed PMID: 30980833.
  • Meyer T, Tiburcy M, Zimmermann WH. Cardiac macrotissues-on-a-plate models for phenotypic drug screens. Adv Drug Deliv Rev. 2019, 140, 93-100. PubMed PMID: 30902615.
  • Trautsch I, Heta E, Soong PL, Levent E, Nikolaev VO, Bogeski I, Katschinski DM, Mayr M, Zimmermann WH. Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium. Front Physiol. 2019, 10, 272. PubMed PMID: 31024328.
  • Sattler K, El-Battrawy I, Zhao Z, Schrottenberg C, Yücel G, Lan H, Li X, Lang S, Zimmermann WH, Cyganek L, Utikal J, Wieland T, Ravens U, Bieback K, Borggrefe M, Zhou X, Akin I. Serum of Patients With Acute Myocardial Infarction Prevents Inflammation in iPSC-cardiomyocytes. Sci Rep. 2019, 9 (1), 565. PubMed PMID: 30948775.
  • Madonna R, Van Laake LW, Botker HE, Davidson SM, De Caterina R, Engel FB, Eschenhagen T, Fernandez-Aviles F, Hausenloy DJ, Hulot J-S, Lecour S, Leor J, Menasché P, Pesce M, Perrino C, Prunier F, Van Linthout S, Ytrehus K, Zimmermann WH, Ferdinandy P, Sluijter JPG. ESC Working Group on Cellular Biology of the Heart: Position Paper for Cardiovascular Research: Tissue Engineering Strategies Combined With Cell Therapies for Cardiac Repair in Ischaemic Heart Disease and Heart Failure. Cardiovasc Res. 2019, 115 (3), 488-500. PubMed PMID: 30657875.
  • de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du X-J, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschöpe C, Zannad F, Zimmermann WH, Ruschitzka F, Fiippatos G, Lindsey ML, Maack C, Heymans S. Towards Better Definition, Quantification and Treatment of Fibrosis in Heart Failure. A Scientific Roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology. Eur J Heart Fail. 2019, 21 (3), 272-285. PubMed PMID: 30714667.
  • Leinhos L, Peters J, Krull S, Helbig L, Vogler M, Levay M, van Belle GJ, Riley AJ, Lutz S, Katschinski DM, Zieseniss A. Hypoxia suppresses myofibroblast differentiation by changing RhoA activity. J Cell Sci. 2019, 132 (5) 2019. PubMed PMID: 30659117.
  • Schlick SF, Spreckelsen F, Tiburcy M, Iyer LM, Meyer T, Zelarayán LC, Luther S, Parlitz U, Zimmermann WH, Rehfeldt F. Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium. Prog Biophys Mol Biol. 2019, 144:51-60. PubMed PMID: 30553553.
  • Thomas D, Christ T, Fabritz L, Goette A, Hammwöhner M, Heijman J, Kockskämper J, Linz D, Odening KE, Schweizer PA, Wakili R, Voigt N. German Cardiac Society Working Group on Cellular Electrophysiology State-Of-The-Art Paper: Impact of Molecular Mechanisms on Clinical Arrhythmia Management. Clin Res Cardiol. 2019, 108 (6), 577-599. PubMed PMID: 30306295.
  • Dworatzek E, Mahmoodzadeh S, Schriever C, Kusumoto K, Kramer L, Santos G, Fliegner D, Leung Y-K, Ho S-M, Zimmermann WH, Lutz S, Regitz-Zagrosek V. Sex-specific Regulation of Collagen I and III Expression by 17β-Estradiol in Cardiac Fibroblasts: Role of Estrogen Receptors. Cardiovasc Res. 2019, 115 (2), 315-327. PubMed PMID: 30016401.
  • Morhenn K, Quentin T, Wichmann H, Steinmetz M, Prondzynski M, Söhren K-D, Christ T, Geertz B, Schröder S, Schöndube FA, Hasenfuss G, Schlossarek S, Zimmermann WH, Carrier L, Eschenhagen T, Cardinaux J-R, Lutz S, Oetjen E. Mechanistic Role of the CREB-regulated Transcription Coactivator 1 in Cardiac Hypertrophy. J Mol Cell Cardiol. 2019, 127, 31-43. PubMed PMID: 30521840.

2018

  • Cyganek L, Tiburcy M, Sekeres K, Gerstenberg K, Bohnenberger H, Lenz C, Henze S, Stauske M, Salinas G, Zimmermann WH, Hasenfuss G, Guan K. Deep Phenotyping of Human Induced Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes. JCI Insight. 2018, 3 (12). PubMed PMID: 29925689.
  • Nicolas J-D, Bernhardt M, Schlick SF, Tiburcy M, Zimmermann WH, Khan A, Markus A, Alves F, Toischer K, Salditt T. X-ray Diffraction Imaging of Cardiac Cells and Tissue. Prog Biophys Mol Biol. 2018, 144, 151-165. PubMed PMID: 29914693.
  • Mohamed BA, Hartmann N, Tirilomis P, Sekeres K, Li W, Neef S, Richter C, Zeisberg EM, Kattner L, Didié M, Guan K, Schmitto JD, Lehnart SE, Luther S, Voigt N, Seidler T, Sossalla S, Hasenfuss G, Toischer K. Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression. Sci Transl Med. 2018, 10 (458). PubMed PMID: 30209242.
  • Zimmermann WH, Yla-Herttuala S, Hajjar RJ. Highlighting the field of cardiovascular regenerative medicine. Mol Ther. 2018, 26 (7), 1595. PubMed PMID: 29934254.
  • Zimmermann WH. Engineered nanoparticles prevent dilation of abdominal aortic aneurysms. J Am Coll Cardiol. 2018, 72 (21), 2606-2608. PubMed PMID: 30466518.
  • El-Battrawy I, Zhao Z, Lan H, Cyganek L, Tombers C, Li X, Buljubasic F, Lang S, Tiburcy M, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou X-B, Akin I. Electrical Dysfunctions in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With an Arrhythmogenic Right Ventricular Cardiomyopathy. Europace. 2018, 20 (FI1), f46-f56. PubMed PMID: 29566126.
  • Zimmermann WH. A scale model of the human ventricle. Nat Biomed Eng. 2018, 2 (12), 888-889. PubMed PMID: 31015732.
  • Gross JC, Zelarayan LC. The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research. Front Cardiovasc Med. 2018 Feb; 5:10. doi: 10.3389/fcvm.2018.00010.
  • Fujita B, Zimmermann WH. Myocardial Tissue Engineering Strategies for Heart Repair: Current State of the Art. Interact Cardiovasc Thorac Surg. 2018, 27 (6), 916-920. PubMed PMID: 30084989.
  • Molina CE, Jacquet E, Ponien P, Muñoz-Guijosa C, Baczkó I, Maier LS, Donzeau-Gouge P, Dobrev D, Fischmeister R, Garnier A. Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart. Cardiovasc Res. 2018 Feb 1;114(2):247-258. doi: 10.1093/cvr/cvx182. PubMed PMID: 29036603.
  • El-Battrawy I, Zhao Z, Lan H, Schünemann JD, Sattler K, Buljubasic F, Patocskai B, Li X, Yücel G, Lang S, Nowak D, Cyganek L, Bieback K, Utikal J, Zimmermann WH, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes. Int J Cardiol. 2018 Mar 1;254:195-202. doi: 10.1016/j.ijcard.2017.11.007. Epub 2018 Jan 28. PubMed PMID: 29407091.
  • Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN. Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing. Sci Adv. 2018 Jan 31;4(1):eaap9004. doi: 10.1126/sciadv.aap9004. eCollection 2018 Jan. PubMed PMID: 29404407.
  • Iyer LM, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, Kari V, Herting J, Pang ST, Weber T, Rathjens FS, Fischer TH, Toischer K, Hasenfuss G, Noack C, Johnsen SA, Zelarayán LC. A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart. Nucleic Acids Res. 2018 Jan 31. doi: 10.1093/nar/gky049. [Epub ahead of print] PubMed PMID: 29394407.
  • Gröschel C, Sasse A, Monecke S, Röhrborn C, Elsner L, Didié M, Reupke V, Bunt G, Lichtman AH, Toischer K, Zimmermann WH, Hasenfuß G, Dressel R. CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure. Front Immunol. 2018, 9, 2665. PubMed PMID: 30498501.
  • Zimmermann WH. Cardiomyocytes Remuscularize the Heart. Nat Biotechnol. 2018, 36 (7), 592-593. PubMed PMID: 29979663.
  • Zhao X, Chen H, Xiao D, Yang H, Itzhaki I, Qin X, Chour T, Aguirre A, Lehmann K, Kim Y, Shukla P, Holmström A, Zhang JZ, Zhuge Y, Ndoye BC, Zhao M, Neofytou E, Zimmermann WH, Jain M, Wu JC. Comparison of Non-human Primate versus Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Treatment of Myocardial Infarction. Stem Cell Reports. 2018 Jan 26. pii: S2213-6711(18)30028-6. doi: 10.1016/j.stemcr.2018.01.002. [Epub ahead of print] PubMed PMID: 29398480.
  • Heijman J, Kirchner D, Kunze F, Chrétien EM, Michel-Reher MB, Voigt N, Knaut M, Michel MC, Ravens U, Dobrev D. Muscarinic type-1 receptors contribute to I(K,ACh) in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. Int J Cardiol. 2018 Mar 15;255:61-68. doi: 10.1016/j.ijcard.2017.12.050. Epub 2017 Dec 22. PubMed PMID: 29290419.
  • Meyer T, Voigt N. In search for novel functions of adenosine 5'-triphosphate (ATP) in the heart. Cardiovasc Res. 2017 Dec 1;113(14):e59-e60. doi: 10.1093/cvr/cvx207. PubMed PMID: 29186438.
  • Voigt N, Mason F, Thomas D. Report on the Ion Channel Symposium: Organized by the German Cardiac Society Working Group on Cellular Electrophysiology (AG 18). Herzschrittmacherther Elektrophysiol. 2018 Jan 8. doi: 10.1007/s00399-017-0549-4. [Epub ahead of print] Review. PubMed PMID: 29313139.
  • Voigt N, Lederer WJ. Niels Voigt talks to W. Jonathan Lederer, keynote lecturer at the "Göttingen Channels" Symposium 2017. Cardiovasc Res. 2018 Feb 1;114(2):e14. doi: 10.1093/cvr/cvx241. PubMed PMID: 29373724.
  • Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P. Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:65-82. doi: 10.1146/annurev-pharmtox-010617-052722. Epub 2017 Oct 13. PubMed PMID: 29029591.
  • Khan FM, Saleh E, Alawadhi H, Harati R, Zimmermann WH, El-Awady R. Inhibition of exosome release by ketotifen enhances sensitivity of cancer cells to doxorubicin. Cancer Biol Ther. 2018 Jan 2;19(1):25-33. doi:10.1080/15384047.2017.1394544. Epub 2017 Dec 15. PubMed PMID: 29244610.

2017

  • Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D. Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. Eur Heart J. 2017 Jun 7;38(22):1764-1774. doi: 10.1093/eurheartj/ehw559. PubMed PMID: 28057773.
  • Meyer T, Voigt N. In search for novel functions of adenosine 5'-triphosphate (ATP) in the heart. Cardiovasc Res. 2017 Dec 1;113(14):e59-e60. doi: 10.1093/cvr/cvx207. PubMed PMID: 29186438.
  • Molina CE, Voigt N. Finding Ms or Mr Right: Which miRNA to target in AF? J Mol Cell Cardiol. 2017 Jan;102:22-25. doi: 10.1016/j.yjmcc.2016.11.007. Epub 2016 Nov 17. PubMed PMID: 27866930.
  • Ji Y, Varkevisser R, Opacic D, Bossu A, Kuiper M, Beekman JDM, Yang S, Khan AP, Dobrev D, Voigt N, Wang MZ, Verheule S, Vos MA, van der Heyden MAG. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590. doi: 10.1111/bph.13869. Epub 2017 Jun 28. PubMed PMID: 28542844.
  • Schmidt C, Wiedmann F, Kallenberger SM, Ratte A, Schulte JS, Scholz B, Müller FU, Voigt N, Zafeiriou MP, Ehrlich JR, Tochtermann U, Veres G, Ruhparwar A, Karck M, Katus HA, Thomas D. Stretch-activated two-pore-domain (K(2P)) potassium channels in the heart: Focus on atrial fibrillation and heart failure. Prog Biophys Mol Biol. 2017 Nov;130(Pt B):233-243. doi: 10.1016/j.pbiomolbio.2017.05.004. Epub 2017 May 16. PubMed PMID: 28526353.
  • Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafčíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D. Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. 2017 Feb;31(2):361-372. doi: 10.1038/leu.2016.232. Epub 2016 Aug 18. PubMed PMID: 27535218.
  • Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, Janovská P, Beissbarth T, Alves F, Klapper W, Bryja V, Pukrop T, Trümper L, Wilting J, Kube D. WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene. 2017 Jan 5;36(1):13-23. doi: 10.1038/onc.2016.183. Epub 2016 Jun 6. PubMed PMID: 27270428 .
  • Wottawa M, Naas S, Böttger J, van Belle GJ, Möbius W, Revelo NH, Heidenreich D, von Ahlen M, Zieseniss A, Kröhnert K, Lutz S, Lenz C, Urlaub H, Rizzoli SO, Katschinski DM. Hypoxia-stimulated membrane trafficking requires T-plastin. Acta Physiol (Oxf). 2017 Sep;221(1):59-73. doi: 10.1111/apha.12859. Epub 2017 Mar 23. PubMed PMID: 28218996.
  • Castillo-Gómez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, Zafeiriou P, Steiner J, Jurek B, Trippe R, Prüss H, Zimmermann WH, Bertrand D, Ehrenreich H, Hollmann M. All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry. 2017 Dec;22(12):1776-1784. doi: 10.1038/mp.2016.125. Epub 2016 Aug 9. PubMed PMID: 27502473.
  • Gröschel C, Sasse A, Röhrborn C, Monecke S, Didié M, Elsner L, Kruse V, Bunt G, Lichtman AH, Toischer K, Zimmermann WH, Hasenfuß G, Dressel R. T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure. Sci Rep. 2017 Nov 22;7(1):15998. doi: 10.1038/s41598-017-16147-1. PubMed PMID: 29167489.
  • Abilez OJ, Tzatzalos E, Yang H, Zhao MT, Jung G, Zöllner AM, Tiburcy M, Riegler J, Matsa E, Shukla P, Zhuge Y, Chour T, Chen VC, Burridge PW, Karakikes I, Kuhl E, Bernstein D, Couture LA, Gold JD, Zimmermann WH, Wu JC. Passive Stretch Induces Structural and Functional Maturation of Engineered Heart Muscle as Predicted by Computational Modeling. Stem Cells. 2018 Feb;36(2):265-277. doi: 10.1002/stem.2732. Epub 2017 Nov 13. PubMed PMID: 29086457.
  • Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P. Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:65-82. doi: 10.1146/annurev-pharmtox-010617-052722. Epub 2017 Oct 13. PubMed PMID: 29029591.
  • Streckfuss-Bömeke K, Tiburcy M, Fomin A, Luo X, Li W, Fischer C, Özcelik C, Perrot A, Sossalla S, Haas J, Vidal RO, Rebs S, Khadjeh S, Meder B, Bonn S, Linke WA, Zimmermann WH, Hasenfuss G, Guan K. Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2017 Dec;113:9-21. doi: 10.1016/j.yjmcc.2017.09.008. Epub 2017 Sep 21. PubMed PMID: 28941705.
  • Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN. Functional correction of dystrophin actin binding domain mutations by genome editing. JCI Insight. 2017 Sep 21;2(18). pii: 95918. doi: 10.1172/jci.insight.95918. [Epub ahead of print] PubMed PMID: 28931764.
  • Noack C, Haupt LP, Zimmermann WH, Streckfuss-Bömeke K, Zelarayán LC. Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation. Stem Cell Res. 2017 Aug;23:127-131. doi: 10.1016/j.scr.2017.07.007. Epub 2017 Jul 11. PubMed PMID: 28925362.
  • Koopman CD, Zimmermann WH, Knöpfel T, de Boer TP. Cardiac optogenetics: using light to monitor cardiac physiology. Basic Res Cardiol. 2017 Aug 31;112(5):56. doi: 10.1007/s00395-017-0645-y. Review. PubMed PMID: 28861604.
  • Didié M, Galla S, Muppala V, Dressel R, Zimmermann WH. Immunological Properties of Murine Parthenogenetic Stem Cell-Derived Cardiomyocytes and Engineered Heart Muscle. Front Immunol. 2017 Aug 14;8:955. doi: 10.3389/fimmu.2017.00955. eCollection 2017. PubMed PMID: 28855904.
  • Johannsen H, Muppala V, Gröschel C, Monecke S, Elsner L, Didié M, Zimmermann WH, Dressel R. Immunological Properties of Murine Parthenogenetic Stem Cells and Their Differentiation Products. Front Immunol. 2017 Aug 4;8:924. doi: 10.3389/fimmu.2017.00924. eCollection 2017. PubMed PMID: 28824647.
  • Borchert T, Hübscher D, Guessoum CI, Lam TD, Ghadri JR, Schellinger IN, Tiburcy M, Liaw NY, Li Y, Haas J, Sossalla S, Huber MA, Cyganek L, Jacobshagen C, Dressel R, Raaz U, Nikolaev VO, Guan K, Thiele H, Meder B, Wollnik B, Zimmermann WH, Lüscher TF, Hasenfuss G, Templin C, Streckfuss-Bömeke K. Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy. J Am Coll Cardiol. 2017 Aug 22;70(8):975-991. doi: 10.1016/j.jacc.2017.06.061. PubMed PMID: 28818208.
  • Fujita B, Zimmermann WH. Myocardial Tissue Engineering for Regenerative Applications. Curr Cardiol Rep. 2017 Sep;19(9):78. doi: 10.1007/s11886-017-0892-4. Review. PubMed PMID: 28752277.
  • Fujita B, Zimmermann WH. Engineered Heart Repair. Clin Pharmacol Ther. 2017 Aug;102(2):197-199. doi: 10.1002/cpt.724. Epub 2017 Jun 29. Review. PubMed PMID: 28661033.
  • Yücel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, Buljubasic F, Zimmermann WH, Cyganek L, Utikal J, Ravens U, Wieland T, Borggrefe M, Zhou XB, Akin I. Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes. Sci Rep. 2017 Jun 7;7(1):2935. doi: 10.1038/s41598-017-03147-4. PubMed PMID: 28592841.
  • Dewenter M, Neef S, Vettel C, Lämmle S, Beushausen C, Zelarayan LC, Katz S, von der Lieth A, Meyer-Roxlau S, Weber S, Wieland T, Sossalla S, Backs J, Brown JH, Maier LS, El-Armouche A. Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure. Circ Heart Fail. 2017 May;10(5):e003840. doi: 10.1161/CIRCHEARTFAILURE.117.003840. PubMed PMID: 28487342.
  • Zimmermann WH. Remuscularization of the failing heart. J Physiol. 2017 Jun 15;595(12):3685-3690. doi: 10.1113/JP273098. Epub 2017 Apr 25. PubMed PMID: 28295371.
  • Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair. Circulation. 2017 May 9;135(19):1832-1847. doi: 10.1161/CIRCULATIONAHA.116.024145. Epub 2017 Feb 6. PubMed PMID: 28167635.
  • Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2017 Feb 28;135(9):881-897. doi: 10.1161/CIRCULATIONAHA.116.022852. Epub 2016 Dec 7. PubMed PMID: 27927712.
  • Zimmermann WH. Translating Myocardial Remuscularization. Circ Res. 2017 Jan 20;120(2):278-281. doi: 10.1161/CIRCRESAHA.116.310194. PubMed PMID: 28104769.

2016

  • Qin X, Riegler J, Tiburcy M, Zhao X, Chour T, Ndoye B, Nguyen M, Adams J, Ameen M, Denney TS Jr, Yang PC, Nguyen P, Zimmermann WH, Wu JC. Magnetic Resonance Imaging of Cardiac Strain Pattern Following Transplantation of Human Tissue Engineered Heart Muscles. Circ Cardiovasc Imaging. 2016 Nov;9(11). pii: e004731. PubMed PMID: 27903535.
  • El-Battrawy I, Lang S, Zhao Z, Akin I, Yücel G, Meister S, Patocskai B, Behnes M, Rudic B, Tülümen E, Liebe V, Tiburcy M, Dworacek J, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou XB. Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One. 2016 Nov 9;11(11):e0166143. doi: 10.1371/journal.pone.0166143. eCollection 2016. PubMed PMID: 27829006.
  • Ogle BM, Bursac N, Domian I, Huang NF, Menasché P, Murry CE, Pruitt B, Radisic M, Wu JC, Wu SM, Zhang J, Zimmermann WH, Vunjak-Novakovic G. Distilling complexity to advance cardiac tissue engineering. Sci Transl Med. 2016 Jun 8;8(342):342ps13. doi: 10.1126/scitranslmed.aad2304. Review. PubMed PMID: 27280684.
  • Zeidler S, Meckbach C, Tacke R, Raad FS, Roa A, Uchida S, Zimmermann WH, Wingender E, Gültas M. Computational Detection of Stage-Specific Transcription Factor Clusters during Heart Development. Front Genet. 2016 Mar 23;7:33. doi: 10.3389/fgene.2016.00033. eCollection 2016. PubMed PMID: 27047536.
  • Zimmermann WH. Strip and Dress the Human Heart. Circ Res. 2016 Jan 8;118(1):12-3. doi: 10.1161/CIRCRESAHA.115.307938. Erratum in: Circ Res. 2016 Mar 18;118(6):e33. PubMed PMID: 26837739.
  • Liaw NY, Zimmermann WH. Mechanical stimulation in the engineering of heart muscle. Adv Drug Deliv Rev. 2016 Jan 15;96:156-60. doi: 10.1016/j.addr.2015.09.001. Epub 2015 Sep 8. Review. PubMed PMID: 26362920.

2015

  • Zimmermann WH. New Biologics for the Modulation of Post-Infarct Remodeling: Matricryptins. J Am Coll Cardiol. 2015 Sep 22;66(12):1375-7. doi: 10.1016/j.jacc.2015.07.039. PubMed PMID: 26383725.
  • Jatho A, Hartmann S, Kittana N, Mügge F, Wuertz CM, Tiburcy M, Zimmermann WH, Katschinski DM, Lutz S. RhoA Ambivalently Controls Prominent Myofibroblast Characteritics by Involving Distinct Signaling Routes. PLoS One. 2015 Oct 8;10(10):e0137519. doi: 10.1371/journal.pone.0137519. eCollection 2015. PubMed PMID: 26448568.
  • Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, Stadler H, Kawabe H, Zimmermann WH, Nave KA, Schulz-Schaeffer W, Jahn O, Ehrenreich H. Widespread expression of erythropoietin receptor in brain and its induction by injury. Mol Med. 2015 Sep 1. doi: 10.2119/molmed.2015.00192. [Epub ahead of print] PubMed PMID: 26349059.
  • Sharma P, Abbasi C, Lazic S, Teng ACT, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015 6: 8391, doi: 10.1038/ncomms9391. PubMed PMID: 26403541.
  • Ongherth A, Pasch S, Wuertz CM, Nowak K, Kittana N, Weis CA, Jatho A, Vettel C, Tiburcy M, Toischer K, Hasenfuss G, Zimmermann WH, Wieland T, Lutz S. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. J Mol Cell Cardiol. 2015 Nov;88:39-54. doi: 10.1016/j.yjmcc.2015.09.009. Epub 2015 Sep 21. PubMed PMID: 26392029.
  • Hartmann S, Ridley AJ, Lutz S. The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Front Pharmacol. 2015 6:276, doi: 10.3389/fphar.2015.00276. PubMed PMID: 26635606.
  • Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen VC, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC. Human Engineered Heart Muscles Engraft and Survive Long Term in a Rodent Myocardial Infarction Model. Circ Res. 2015 117(8): 720-30, doi: 10.1161/CIRCRESAHA.115.306985. PubMed PMID: 26291556.
  • Yang T, Rubart M, Soonpaa MH, Didié M, Christalla P, Zimmermann WH, Field LJ. Cardiac engraftment of genetically-selected parthenogenetic stem cell-derived cardiomyocytes. PLoS One. 2015 Jun 25;10(6):e0131511. doi: 10.1371/journal.pone.0131511. eCollection 2015. PubMed PMID: 26110646.
  • Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator. Circ Res. 2015 Aug 14;117(5):401-12. doi: 10.1161/CIRCRESAHA.117.306143. Epub 2015 Jun 15. PubMed PMID: 26078285.
  • Ritterhoff J, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger ST, Zimmermann WH, Friedrich O, Fink RHA, Koch WJ, Katus HA, Most P. S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction. Mol Ther. 2015 23(8): 1320-30, doi: 10.1038/mt.2015.93. PubMed PMID: 26005840.
  • Godier-Furnémont AF, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials. 2015 Aug;60:82-91. doi: 10.1016/j.biomaterials.2015.03.055. Epub 2015 May 15. PubMed PMID: 25985155.
  • Unsöld B, Bremen E, Didié M, Hasenfuss G, Schäfer K. Differential PI3K signal transduction in obesity-associated cardiac hypertrophy and response to ischemia. Obesity. 2015 23(1): 90-9, doi: 10.1002/oby.20888. PubMed PMID: 25175008.
  • Unsöld B, Teucher N, Didié M, Sossalla S, Jacobshagen C, Seidler T, Schillinger W, Hasenfuß G. Negative hemodynamic effects of pantoprazole at high infusion rates in mice. Cardiovasc Ther. 2015 33(1): 20-6, doi: 10.1111/1755-5922.12102. PubMed PMID: 25529757.
  • Vogler M, Zieseniss A, Hesse AR, Levent E, Tiburcy M, Heinze E, Burzlaff N, Schley G, Eckardt KU, Willam C, Katschinski DM. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflug Arch Eur J Phy. 2015 467(10): 2141-9, doi: 10.1007/s00424-014-1667-z. PMID: 25578858.

2014

  • Izarra A, Moscoso I, Levent E, Cañón S, Cerrada I, Díez-Juan A, Blanca V, Núñez-Gil IJ, Valiente I, Ruíz- Sauri A, Sepúlveda P, Tiburcy M, Zimmermann WH, Bernad A. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Reports. 2014 3(6): 1029-42, doi: 10.1016/j.stemcr.2014.10.010. PubMed PMID: 25465869.
  • Hesse AR, Levent E, Zieseniss A, Tiburcy M, Zimmermann WH, Katschinski DM. Lights on for HIF-1α: genetically enhanced mouse cardiomyocytes for heart tissue imaging. Cell Physiol Biochem. 2014 34(2): 455-62, doi: 10.1159/000363014. PubMed PMID: 25095893.
  • Tiburcy M, Meyer T, Soong PL, Zimmermann WH. Collagen-based engineered heart muscle. Methods Mol Biol. 2014;1181:167-76. doi: 10.1007/978-1-4939-1047-2_15. PubMed PMID: 25070336.
  • Zafiriou MP, Noack C, Unsöld B, Didie M, Pavlova E, Fischer HJ, Reichardt HM, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayan LC. Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction. Stem Cells. 2014 Sep;32(9):2480-91. doi: 10.1002/stem.1741. PubMed PMID: 24806289.
  • Zimmermann WH. [Individualized stem cell therapy]. Herz. 2014 39(2): 201-5, doi: 10.1007/s00059-014- 4073-6. PubMed PMID: 24589843.
  • Vettel C, Lämmle S, Ewens S, Cervirgen C, Emons J, Ongherth A, Dewenter M, Lindner D, Westermann D, Nikolaev VO, Lutz S, Zimmermann WH, El-Armouche A. PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways. Am J Physiol-Heart C. 2014 306(8): H1246-52, doi: 10.1152/ajpheart.00852.2013. PubMed PMID: 24531807.
  • Didié M, Zimmermann WH. Ultrasound techniques for the detection of tumors and metastases in small animals. Methods Mol Biol. 2014 1070: 181-90, doi: 10.1007/978-1-4614-8244-4_13. PubMed PMID: 24092440.
  • Tiburcy M, Zimmermann WH. Modeling myocardial growth and hypertrophy in engineered heart muscle. Trends Cardiovas Med. 2014 24(1): 7-13, doi: 10.1016/j.tcm.2013.05.003. PubMed PMID: 23953977.
  • Kararigas G, Nguyen BT, Zelarayan LC, Hassenpflug M, Toischer K, Sanchez-Ruderisch H, Hasenfuss G, Bergmann MW, Jarry H, Regitz-Zagrosek V. Genetic background defines the regulation of postnatal cardiac growth by 17β-estradiol through a β-catenin mechanism. Endocrinology. 2014 155(7): 2667-76, doi: 10.1210/en.2013-2180. PubMed PMID: 24731099.
  • Bodmann EL, Rinne A, Brandt D, Lutz S, Wieland T, Grosse R, Bünemann M. (2014) Dynamics of Gαq- protein-p63RhoGEF interaction and its regulation by RGS2. Biochem J. 2014 458(1): 131-40, doi: 10.1042/BJ20130782. PubMed PMID: 24299002.
  • Dewenter M, Vettel C, El-Armouche A. The Janus face of BNP therapy in chronic heart failure: beneficial effects unmasked by β blockers? Heart. 2014 100(11): 819-20, doi: 10.1136/heartjnl-2014-305503. PubMed PMID: 24667282.
  • Döker S, Dewenter M, El-Armouche A. [Tofacitinib]. Deut Med Wochenschr. 2014 139(19): 1003-8, doi: 10.1055/s-0034-1369986. PubMed PMID: 24782154.
  • Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res. 2014 102(1): 97-106, doi: 10.1093/cvr/cvu029. PubMed PMID: 24550350.
  • Neuber C, Müller OJ, Hansen FC, Eder A, Witten A, Rühle F, Stoll M, Katus HA, Eschenhagen T, El-Armouche A. Paradoxical effects on force generation after efficient β1-adrenoceptor knockdown in reconstituted heart tissue. J Pharmacol Exp Ther. 2014 349(1): 39-46, doi: 10.1124/jpet.113.210898. PubMed PMID: 24431469.
  • Neuber C, Uebeler J, Schulze T, Sotoud H, El-Armouche A, Eschenhagen T. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. Plos One. 2014 9(6): e98893, doi: 10.1371/journal.pone.0098893. PubMed PMID: 24892553.
  • Salamon J, Wicklein D, Didié M, Lange C, Schumacher U, Adam G, Peldschus K. Magnetic resonance imaging of single co-labeled mesenchymal stromal cells after intracardial injection in mice. Rofo-Fortschr Rontg. 2014 186(4): 367-76, doi: 10.1055/s-0034-1366097. PubMed PMID: 24683169.
  • Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. Cardiovasc Res. 2014 101(1): 97-107, doi: 10.1093/cvr/cvt235. PubMed PMID: 24130190.
  • Vettel C, Hottenrott MC, Spindler R, Benck U, Schnuelle P, Tsagogiorgas C, Krämer BK, Hoeger S, El-Armouche A, Wieland T, Yard BA. Dopamine and lipophilic derivates protect cardiomyocytes against cold preservation injury. J Pharmacol Exp Ther. 2014 348(1): 77-85, doi: 10.1124/jpet.113.207001. PubMed PMID: 24135075.
  • Zschüntzsch J, Jouvenal P, Zhang Y, Klinker F, Tiburcy M, Malzahn D, Liebetanz D, Brinkmeier H, Schmidt J. Human immunoglobulin G for experimental treatment of Duchenne muscular dystrophy. Clin Exp Immunol. 178 Suppl 1: 132-3, doi: 10.1111/cei.12541. PubMed PMID: 25546792.

2013

  • Zimmermann WH. Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair. Stem Cell Res Ther. 2013;4(6):137. Review. PubMed PMID: 24229468.
  • Ye L, Zimmermann WH, Garry DJ, Zhang J. Patching the heart: cardiac repair from within and outside. Circ Res. 2013 Sep 13;113(7):922-32. doi: 10.1161/CIRCRESAHA.113.300216. Review. PubMed PMID: 24030022.
  • Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013 Oct 25;113(10):1138-47. doi: 10.1161/CIRCRESAHA.113.302400. Epub 2013 Sep 4. PubMed PMID: 24006456.
  • Schwoerer AP, Neef S, Broichhausen I, Jacubeit J, Tiburcy M, Wagner M, Biermann D, Didié M, Vettel C, Maier LS, Zimmermann WH, Carrier L, Eschenhagen T, Volk T, El-Armouche A, Ehmke H. Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading. Pflugers Arch. 2013 Dec;465(12):1763-73. doi: 10.1007/s00424-013-1316-y. Epub 2013 Jul 11. PubMed PMID: 23842739.
  • Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. PubMed PMID: 23810893.
  • Didié M, Biermann D, Buchert R, Hess A, Wittköpper K, Christalla P, Döker S, Jebran F, Schöndube F, Reichenspurner H, El-Armouche A, Zimmermann WH. Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants. Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H533-41. doi: 10.1152/ajpheart.00218.2013. Epub 2013 Jun 14. PubMed PMID: 23771692.
  • Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. Parthenogenetic stem cells for tissue-engineered heart repair. J Clin Invest. 2013 Mar;123(3):1285-98. doi: 10.1172/JCI66854. Epub 2013 Feb 22. PubMed PMID: 23434590.
  • Renger A, Zafiriou MP, Noack C, Pavlova E, Becker A, Sharkova K, Bergmann MW, El-Armouche A, Zimmermann WH, Zelarayán LC. The four and a half LIM-domain 2 controls early cardiac cell commitment and expansion via regulating β-catenin-dependent transcription. Stem Cells. 2013 May;31(5):928-40. doi: 10.1002/stem.1332. PubMed PMID: 23341242.
  • Karikkineth BC, Zimmermann WH. Myocardial tissue engineering and heart muscle repair. Curr Pharm Biotechnol. 2013;14(1):4-11. Review. PubMed PMID: 23092254.
  • Streckfuss-Bömeke K, Wolf F, Azizian A, Stauske M, Tiburcy M, Wagner S, Hübscher D, Dressel R, Chen S, Jende J, Wulf G, Lorenz V, Schön MP, Maier LS, Zimmermann WH, Hasenfuss G, Guan K. Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts. Eur Heart J. 2013 Sep;34(33):2618-29. doi: 10.1093/eurheartj/ehs203. Epub 2012 Jul 12. PubMed PMID: 22798560.
  • Vogler M, Vogel S, Krull S, Farhat K, Leisering P, Lutz S, Wuertz CM, Katschinski DM, Zieseniss A. Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution. PLoS One. 2013 Jul 18;8(7):e69128. doi: 10.1371/journal.pone.0069128. Print 2013. PubMed PMID: 23874890.
  • Schroeter MR, Leifheit-Nestler M, Hubert A, Schumann B, Glückermann R, Eschholz N, Krüger N, Lutz S, Hasenfuss G, Konstantinides S, Schäfer K. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovasc Res. 2013 Aug 1;99(3):555-65. doi: 10.1093/cvr/cvt126. Epub 2013 May 30. PubMed PMID: 23723060.
  • Hippe HJ, Lüdde M, Schnoes K, Novakovic A, Lutz S, Katus HA, Niroomand F, Nürnberg B, Frey N, Wieland T. Competition for Gβγ dimers mediates a specific cross-talk between stimulatory and inhibitory G protein α subunits of the adenylyl cyclase in cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):459-69. doi: 10.1007/s00210-013-0876-x. Epub 2013 Apr 26. PubMed PMID: 23615874.
  • Lutz S, Mohl M, Rauch J, Weber P, Wieland T. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase Iα. 23195829.
  • Didié M, Zimmermann WH. Ultrasound techniques for the detection of tumors and metastases in small animals. Methods Mol Biol. 2014;1070:181-90. doi: 10.1007/978-1-4614-8244-4_13. PMID: 24092440

2012

  • Biermann D, Heilmann A, Didié M, Schlossarek S, Wahab A, Grimm M, Römer M, Reichenspurner H, Sultan KR, Steenpass A, Ergün S, Donzelli S, Carrier L, Ehmke H, Zimmermann WH, Hein L, Böger RH, Benndorf RA (2012) Impact of AT2 receptor deficiency on postnatal cardiovascular development. PLOS ONE 7(10): e47916, doi: 10.1371/journal.pone.0047916.
  • Carbajo-Lozoya J, Lutz S, Feng Y, Kroll J, Hammes HP, Wieland T (2012) Angiotensin II modulates VEGFdriven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium. CELL SIGNAL 24(6): 1261-9, doi: 10.1016/j.cellsig.2012.02.005.
  • Christalla P, Dewenter M, El-Armouche A (2012) [Effectiveness and safety of varenicline for smoking cessation]. DEUT MED WOCHENSCHR 137(18): 940-4, doi: 10.1055/s-0032-1304895 4. Christalla P, Hudson JE, Zimmermann WH (2012) The cardiogenic niche as a fundamental building block of engineered myocardium. CELLS TISSUES ORGANS 195(1-2): 82-93, doi: 10.1159/000331407.
  • Fredersdorf S, Thumann C, Zimmermann WH, Vetter R, Graf T, Luchner A, Riegger GA, Schunkert H, Eschenhagen T, Weil J (2012) Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. CARDIOVASC DIABETOL 11: 57, doi: 10.1186/1475-2840-11-57.
  • Hölscher M, Schäfer K, Krull S, Farhat K, Hesse A, Silter M, Lin Y, Pichler BJ, Thistlethwaite P, El-Armouche A, Maier LS, Katschinski DM, Zieseniss A (2012) Unfavourable consequences of chronic cardiac HIF-1α stabilization. CARDIOVASC RES 94(1): 77-86, doi: 10.1093/cvr/cvs014.
  • Mohamed BA, Barakat AZ, Zimmermann WH, Bittner RE, Mühlfeld C, Hünlich M, Engel W, Maier LS, Adham IM (2012) Targeted disruption of Hspa4 gene leads to cardiac hypertrophy and fibrosis. J MOL CELL CARDIOL 53(4): 459-68, doi: 10.1016/j.yjmcc.2012.07.014.
  • Noack C, Zafiriou MP, Schaeffer HJ, Renger A, Pavlova E, Dietz R, Zimmermann WH, Bergmann MW,Zelarayán LC (2012) Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart. EMBO MOL MED 4(9): 992-1007, doi: 10.1002/emmm.201101043.
  • Soong PL, Tiburcy M, Zimmermann WH (2012) Cardiac differentiation of human embryonic stem cells and their assembly into engineered heart muscle. Curr Protoc Cell Biol Chapter 23: Unit23.8, doi: 10.1002/0471143030.cb2308s55.
  • Unsöld B, Schotola H, Jacobshagen C, Seidler T, Sossalla S, Emons J, Klede S, Knöll R, Guan K, El-Armouche A, Linke WA, Kögler H, Hasenfuss G (2012) Age-dependent changes in contractile function and passive elastic properties of myocardium from mice lacking muscle LIM protein (MLP). EUR J HEART FAIL 14(4): 430-7, doi: 10.1093/eurjhf/hfs020.
  • Vettel C, Wittig K, Vogt A, Wuertz CM, El-Armouche A, Lutz S, Wieland T (2012) A novel player in cellular hypertrophy: Giβγ/PI3K-dependent activation of the RacGEF TIAM-1 is required for α₁-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes. J MOL CELL CARDIOL 53(2): 165-75, doi: 10.1016/j.yjmcc.2012.04.015.
  • Eschenhagen T, Zimmermann WH (2012) Engineered Heart Tissue. In: Felix B Engel (ed.) Heart Regeneration - Stem Cells and Beyond. World Scientific, 299-326.
  • Zelarayán L, Zafiriou MP, Zimmermann WH (2012) Emerging Concepts in Myocardial Pharmacoregeneration. In: Gustav Steinhoff (ed.) Regenerative Medicine, From Protocol to Patient. Springer, 637-664.

2011

  • Caglayan E, Vantler M, Leppänen O, Gerhardt F, Mustafov L, Ten Freyhaus H, Kappert K, Odenthal M, Zimmermann WH, Tallquist MD, Rosenkranz S (2011) Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase C 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo. J AM COLL CARDIOL 57(25): 2527-38.doi: 10.1016/j.jacc.2011.02.037
  • El-Armouche A, Ouchi N, Tanaka K, Doros G, Wittköpper K, Schulze T, Eschenhagen T, Walsh K, Sam F (2011) Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling. CIRC-HEART FAIL 4(5): 621-7. DOI: 10.1161/CIRCHEARTFAILURE.110.960625
  • El-Armouche A, Wittköpper K, Fuller W, Howie J, Shattock MJ, Pavlovic D (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB J 25(12): 4467-75.DOI: 10.1096/fj.11-184903
  • Grebe C, Klingebiel TM, Grau SP, Toischer K, Didié M, Jacobshagen C, Dullin C, Hasenfuss G, Seidler T (2011) Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. CARDIOVASC RES. 27 Jan 2011, 90(3):521-528. DOI: 10.1093/cvr/cvr023
  • Hippe HJ, Wolf NM, Abu-Taha HI, Lutz S, Le Lay S, Just S, Rottbauer W, Katus HA, Wieland T (2011) Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. N-S ARCH PHARMACOL 384(4-5): 461-72.DOI: 10.1007/s00210-011-0618-x
  • Hudson JE, Zimmermann WH (2011) Tuning Wnt-signaling to enhance cardiomyogenesis in human embryonic and induced pluripotent stem cells. J MOL CELL CARDIOL 51(3): 277-9. DOI: 10.1016/j.yjmcc.2011.06.011
  • Huntgeburth M, Tiemann K, Shahverdyan R, Schlüter KD, Schreckenberg R, Gross ML, Mödersheim S, Caglayan E, Müller-Ehmsen J, Ghanem A, Vantler M, Zimmermann WH, Böhm M, Rosenkranz S (2011) Transforming growth factor? oppositely regulates the hypertrophic and contractile response to –adrenergic stimulation in the heart. PLOS ONE 6(11): e26628. doi: 10.1093/cvr/cvz049
  • Kehat I, Davis J, Tiburcy M, Accornero F, Saba-El-Leil MK, Maillet M, York AJ, Lorenz JN, Zimmermann WH, Meloche S, Molkentin JD (2011) Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth. CIRC RES 108(2): 176-83. doi: 10.3389/fphar.2015.00149
  • Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJR, Sattler M, Wilmanns M, Chien KR (2011) Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. CIRC RES 109(7): 758-69, doi: 10.1161/CIRCRESAHA.111.245787. DOI: 10.1161/CIRCRESAHA.111.245787
  • Naito H, Dohi Y, Zimmermann WH, Tojo T, Takasawa S, Eschenhagen T, Taniguchi S (2011) The effect of mesenchymal stem cell osteoblastic differentiation on the mechanical properties of engineered bone-like tissue. TISSUE ENG PT A 17(17-18): 2321-9. DOI: 10.1089/ten.TEA.2011.0099
  • Naito H, Tojo T, Kimura M, Dohi Y, Zimmermann WH, Eschenhagen T, Taniguchi S (2011) Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels. INTERACT CARDIOV TH 12(2): 156-61. DOI: 10.1510/icvts.2010.253559
  • Phu DT, Wallbach M, Depatie C, Fu A, Screaton RA, Oetjen E (2011) Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels. CELL SIGNAL 23(2): 344-53, doi: 10.1016/j.cellsig.2010.10.001.
  • Schaaf S, Shibamiya A, Mewe M, Eder A, Stöhr A, Hirt MN, Rau T, Zimmermann WH, Conradi L, Eschenhagen T, Hansen A (2011) Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology. PLOS ONE 6(10): e26397. DOI: 10.1371/journal.pone.0026397
  • Sossalla S, Maurer U, Schotola H, Hartmann N, Didié M, Zimmermann WH, Jacobshagen C, Wagner S, Maier LS (2011) Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current. BASIC RES CARDIOL 106(2): 263-72, doi: 10.1007/s00395-010-0136-x.
  • Thoms KM, Kuschal C, Oetjen E, Mori T, Kobayashi N, Laspe P, Boeckmann L, Schön MP, Emmert S (2011) Cyclosporin A, but not everolimus, inhibits DNA repair mediated by calcineurin: implications for tumorigenesis under immunosuppression. EXP DERMATOL 20(3): 232-6, doi: 10.1111/j.1600-0625.2010.01213.x.
  • Tiburcy M, Didié M, Boy O, Christalla P, Döker S, Naito H, Karikkineth BC, El-Armouche A, Grimm M, Nose M, Eschenhagen T, Zieseniss A, Katschinksi D, Hamdani N, Linke WA, Yin X, Mayr M, Zimmermann WH (2011) Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue. CIRC RES 109(10): 1105-14. DOI: 10.1161/CIRCRESAHA.111.251843
  • Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K (2011) Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. CIRCULATION 123(20): 2192-203. DOI: 10.1161/CIRCULATIONAHA.110.016683
  • Wittköpper K, Emons J, El-Armouche A (2011) [Febuxostat]. DEUT MED WOCHENSCHR 136(23): 1270-4.
  • Wittköpper K, Dobrev D, Eschenhagen T, El-Armouche A (2011) Phosphatase-1 inhibitor-1 in physiological and pathological -adrenoceptor signalling. CARDIOVASC RES 91(3): 392-401.
  • Zafiriou MP, Zelarayan LC, Noack C, Renger A, Nigam S, Siafaka-Kapadai A (2011) Hepoxilin A(3) protects β-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. Bichim Biophsy Acta 1811(6): 361-9, doi: 10.1016/j.bbalip.2011.03.002.
  • Zimmermann WH (2011) Embryonic and embryonic-like stem cells in heart muscle engineering. J MOL CELL CARDIOL 50(2): 320-6. DOI: 10.1016/j.yjmcc.2010.10.027
  • Zimmermann WH (2011) Tissue Engineered Myocardium. In: A.R. Boccaccini, S.E. Harding (ed.) Studies in Mechanobiology, Tissue Engineering and Biomaterials. Springer, Berlin - Heidelberg, 111-32

2010

  • El-Armouche A, Schwoerer AP, Neuber C, Emons J, Biermann D, Christalla T, Grundhoff A, Eschenhagen T, Zimmermann WH, Ehmke H (2010) Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load. PLOS ONE 5(12): e14263. DOI: 10.1371/journal.pone.0014263
  • El-Armouche A, Wahab A, Wittköpper K, Schulze T, Böttcher F, Pohlmann L, King SB, DuMond JF, Gerloff C, Böger RH, Eschenhagen T, Carrier L, Donzelli S (2010) The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and -adrenergically desensitized ventricular myocytes. BIOCHEM BIOPH RES CO 402(2): 340-4. DOI: 10.1016/j.bbrc.2010.10.030
  • Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier L, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR (2010) A common MLP (muscle LIM protein) variant is associated with cardiomyopathy.CIRC RES 106(4): 695-704, doi: 10.1161/CIRCRESAHA.109.206243.
  • Rudolph V, Andrié RP, Rudolph TK, Friedrichs K, Klinke A, Hirsch-Hoffmann B, Schwoerer AP, Lau D, Fu X, Klingel K, Sydow K, Didié M, Seniuk A, von Leitner EC, Szoecs K, Schrickel JW, Treede H, Wenzel U, Lewalter T, Nickenig G, Zimmermann WH, Meinertz T, Böger RH, Reichenspurner H, Freeman BA, Eschenhagen T, Ehmke H, Hazen SL, Willems S, Baldus S (2010) Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. NAT MED 16(4): 470-4. DOI: 10.1038/nm.2124
  • Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittköpper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS (2010) Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. CIRC RES 107(9): 1150-616. DOI: 10.1161/CIRCRESAHA.110.220418
  • Vantler M, Karikkineth BC, Naito H, Tiburcy M, Didié M, Nose M, Rosenkranz S, Zimmermann WH (2010) PDGF-BB protects cardiomyocytes from apoptosis and improves contractile function of engineered heart tissue. J MOL CELL CARDIOL 48(6): 1316-23. DOI: 10.1016/j.yjmcc.2010.03.008
  • Wehrhan F, Nkenke E, Melnychenko I, Amann K, Schlegel KA, Goerlach C, Zimmermann WH, Schultze-Mosgau S (2010) Skin repair using a porcine collagen I/III membrane--vascularization and epithelizationproperties. DERMATOL SURG 36(6): 919-30. DOI: 10.1111/j.1524-4725.2010.01569.x
  • Wittköpper K, Eschenhagen T, El-Armouche A (2010) Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress? BASIC RES CARDIOL 105(5): 569-71. DOI: 10.1007/s00395-010-0107-2
  • Wittköpper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuss G, Dobrev D, Eschenhagen T, El-Armouche A (2010) Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J CLIN INVEST 120(2): 617-26. DOI: 10.1172/JCI40545
  • Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S (2010) p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells. FASEB J 24(12): 4865-76. DOI: 10.1096/fj.10-155499

2009

  • Deuse T, Peter C, Fedak PWM, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S (2009) Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. CIRCULATION 120(11): S247-54. DOI: 10.1161/CIRCULATIONAHA.108.843680
  • Hentze H, Soong PL, Wang ST, Phillips BW, Putti TC, Dunn NR (2009) Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies. STEM CELL RES 2(3): 198-210, doi: 10.1016/j.scr.2009.02.002.
  • Zimmermann WH (2009) Remuscularizing failing hearts with tissue engineered myocardium. ANTIOXID REDOX SIGN 11(8): 2011-23 4. DOI: 10.1089/ars.2009.2467
  • Zimmermann WH, Cesnjevar R (2009) Cardiac tissue engineering: implications for pediatric heart surgery. PEDIATR CARDIOL 30(5): 716-23. DOI: 10.1007/s00246-009-9405-6
  • Steinfelder HJ (2009) Hypothalamische und hypophysäre Hormone. In: Aktories, Förstermann, Hofmann und Starke (ed.) Allgemeine und Spezielle Pharmakologie und Toxikologie. Elsevier Science, München, 637-659.
  • Steinfelder HJ (2009) Schilddrüsentherapeutika. In: Aktories, Förstermann, Hofmann und Starke (ed.) Allgemeine und Spezielle Pharmakologie und Toxikologie. Elsevier, München, 717-729.
  • Steinfelder HJ, Oetjen E (2009) Nebennierenrindenhormone. In: Aktories, Förstermann, Hofmann und Starke (ed.) Allgemeine und Spezielle Pharmakologie und Toxikologie. Elsevier, München, 659-683.

2008

  • Zimmermann WH (2008) Tissue engineering: polymers flex their muscles. NAT MATER 7(12): 932-3. DOI: 10.1038/nmat2328

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