Curriculum Vitae
Prof. Dr. med. Wolfram-Hubertus Zimmermann
Prof. Dr. med. Wolfram-Hubertus Zimmermann
Department of Pharmacology and Toxicology,
University Medical Center Goettingen,
Robert-Koch-Str. 40, 37075 Goettingen
Germany
E-mail: w.zimmermann(at)med.uni-goettingen.de
Secretary
Ms. Jutta Creydt
Tel: +49 (0) 551 3965781
Fax: +49 (0) 551 395699
E-mail: sekretariat.pharma(at)med.uni-goettingen.de
Education
| Education | |
|---|---|
| 2007 | Habilitation and Venia Legendi, Pharmacology and Toxicology |
| 2006 | Board Certification in Pharmacology and Toxicology |
| 1995-2000 | Experimental Thesis in Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany |
| 1998-2001 | Postgraduate course in Molecular Biology, Center for Molecular Neurobiology and Institute of Pharmacology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany |
| 1991-1998 | M.D., University Medical Center Hamburg-Eppendorf, Hamburg, Germany |
Clinical electives at:
- Duke University Medical School, Durham, USA
- Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
- Mount Auburn Hospital, Harvard Medical School, Boston, USA
- Groote Schuur Hospital, University of Cape Town, South Africa
Academic Career
- since 2008: Professor (W3) and Director, Department of Pharmacology and Toxicology, University Medical Center Göttingen, Germany
- 2004 - 2008: Junior Professor (Assistant Professor), Institute of Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 2003 - 2004: Lecturer and Staff Scientist, Institute of Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- 1999 - 2003: Resident, Clinical Pharmacology, University Erlangen-Nuremberg
Fellowships, Awards, and Honours (selected)
| Fellowships, Awards, and Honours (selected) | |
|---|---|
| 2021 | Honorary Award Lecture on Basic Science, German Society of Cardiology |
| 2018 | President, 3rd German Pharm Tox Summit / 84th Annual Meeting of the German Society of Pharmacology and Toxicology |
| 2015 | International Engagement Award, Basic Cardiovascular Science Council, AHA |
| 2014 | Start-Up-Innovation Award by the Göttingen County |
| 2008 | Fellow of the American Heart Association (AHA) |
| 2007 | Dr. Martini Award by the Dr. Martini-Stiftung |
| 2007 | Hengstberger-Stipend by the German Society of Cardiology |
| 2005 | Fraenkel-Award by the German Society of Cardiology |
| 2004 | Young Investigator Award (European Section) by the International Society for Heart Research |
| 2002 | Minerva Short-Term Research Stipend at the Gepstein lab (Technion, Haifa, Isreal) by the Max-Planck Society |
| 2001 | Research-Award for Development of Research Tools to Reduce Animal Experiments by the Federal Ministry of Food, Agriculture and Consumer Protection |
| 2001 | Oskar-Lapp-Award by the German Society of Cardiology |
Professional Activities
Editorial Boards
- Circulation Research
- Journal of Molecular and Cellular Cardiology
- Cardiovascular Research
- Basic Research in Cardiology
- Regenerative Therapy
Memberships
- German Society of Pharmacology and Toxicology (DGPT)
- German Society of Cardiology (DGK)
- European Society of Cardiology (ESC)
- American Heart Association (AHA)
- International Society of Heart Research (ISHR)
- International Society for Stem Cell Research (ISSCR)
- Safety Pharmacology Society (SPS)
Research Interests
Tissue-engineered heart repair, therapeutic genome editing, stem cell biology, disease modelling and drug discovery in stem cell models, cell-cell/organ-organ cross talk, translation from bench-to-bedside, early clinical trials, ATMPs
Selected Publications
- Zimmermann WH, Fink C, Kralisch D, Remmers U, Weil J, Eschenhagen T. (2000) Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes. Biotechnol Bioeng 68:106-114. [PubMed]
- Zimmermann WH, Schneiderbanger K, Schubert P, Didie M, Munzel F, Heubach JF, Kostin S, Neuhuber WL, Eschenhagen T. (2002) Tissue engineering of a differentiated cardiac muscle construct. Circ Res 90:223-230. [PubMed]
- Zimmermann WH, Melnychenko I, Wasmeier G, Didie M, Naito H, Nixdorff U, Hess A, Budinsky L, Brune K, Michaelis B, Dhein S, Schwoerer A, Ehmke H, Eschenhagen T. (2006) Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med 12:452-458. [PubMed]
- Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH (2020) Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids. Nat Commun. 11:3791. PMID: 32728089
- Raad FS, Khan TA, Esser TU, Hudson JE, Seth BI, Fujita B, Gandamala R, Tietze LF, Zimmermann WH. (2021) Chalcone-Supported Cardiac Mesoderm Induction in Human Pluripotent Stem Cells for Heart Muscle Engineering. ChemMedChem. 16:3300-3305. PMID: 34309224
- Didié M, Christalla P, Rubart M, Muppala V, Döker S, Unsöld B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Schöler HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. (2013) Parthenogenetic Stem Cells for Tissue Engineered Heart Repair. J Clin Invest 123:1285-1298. [PubMed]
- Godier-Furnémont AFG, Tiburcy M, Wagner E, Dewenter M, Lämmle S, El-Armouche A, Lehnart SE, Vunjak-Novakovic G, Zimmermann WH. (2015) Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation. Biomaterials 60:82-91 [PubMed]
- Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S,Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH. Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator. Circ Res. 2015 Aug 14;117(5):401-12. [PubMed]
- Riegler J§, Tiburcy M§, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH*, Wu JC*. (2015) Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model. Circ Res 117:720-739. §first authors; *corresponding authors [PubMed]
- Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH. (2017) Defined Engineered Human Myocardium with Advanced Maturation for Applications in Heart Failure Modelling and Repair. Circulation 135:1832-1847. [PubMed]