Engineered human myocardium
Principal Investigator: Prof. Dr. med. Wolfram-Hubertus Zimmermann
Remuscularization of the failing human heart is an overarching research interest of the Zimmermann lab. Engineered heart muscle (EHM) is being developed towards clinical applications in heart failure repair. Multiplexing EHM and their combination with other engineered macro organs for applications in the discovery of regenerative therapies is another goal of the Zimmermann lab. This includes studies of organ-to-organ and cell-to-cell cross talk in health and disease. Human pluripotent stem cell models, tissue engineering, and genetic engineering as well as a systems approach, integrating functional phenotypes with morphology and omics data, may serve to better understand disease mechanisms and develop novel pharmacological interventions.
Projects in the lab are primarily developed based on the intention to treat degenerative diseases in heart and brain.