Automated Inotropy and Chronotropy Screens in Engineered Human Myocardium
Engineered tissue surrogates offer an animal-free testbed for safety and efficacy screens of cardio active compounds. Standard organ-bath methods are well established but require significant amounts of tissue handling by expert personnel making them prohibitively costly for large scale screening campaigns. Over the past years we have developed and established a novel multi titer plate that allows to make, grow, and analyze up to 48 tissue constructs in parallel. Analysis and stimulation can be done video-optically, sterility can be maintained unlike in organ bath measurements multiple analysis long-term culture and treatment period can be taken.
3D Extrusion Bioprinting
The driving force of our research is to bring our research from the lab into the clinic, as currently under way with our engineered heart muscle patches. To gain flexibility in design and individualization of large patches we are developing a 3D extrusion bio-printing system. The aim is to create patches made up of interwoven muscle fibers with defined force pattern.
Available for research student supervision? Yes.
Tim Meyer, Malte Tiburcy, WH Zimmermann. Cardiac macrotissues-on-a-plate models for phenotypic drug screens. Adv Drug Deliv Rev. 2019, doi: 10.1016/j.addr.2019.03.002[PubMed]
Montse Barbany, Tim Meyer, .., Xavier de la Cruz. Molecular dynamics study of naturally existing cavity couplings in proteins. PLoS One. 2015 doi: 10.1371/journal.pone.0119978. [PubMed]
Tim Meyer, Valérie Gabelica, Helmut Grubmüller, Modesto Orozco. Proteins in the gas phase Interdisciplinary Reviews: Computational Molecular Science 2012 DOI 10.1002/wcms.1130 [Wiley Online Library]
Ulf Hensen, Tim Meyer, Jürgen Haas, René Rex, Gert Vriend, Helmut Grubmüller. Exploring protein dynamics space: The dynasome as the missing link between structure and function. PloS ONE 2012 (7) e33931. [PubMed]
Tim Meyer, Marco D’Abramo, Adam Hospital, Manuel Rueda, Carles Ferrer-Costa, Alberto Perez, Oliver Carrillo, Jordi Camps, Carles Fenollosa, Dmitry Repchevsky, Josep Lluis Gelpı, and Modesto Orozco, MoDEL (Molecular Dynamics Extended Library): A Database of Atomistic Molecular Dynamics Trajectories. Structure 2010 (11) 1399 - 1409. [PubMed]
Tim Meyer, Xavier de la Cruz, Modesto Orozco. An Atomistic View to the Gas Phase Proteome. Structure 2009 (17) 88-95. [PubMed]
Manuel Rueda, Carles Ferrer-Costa, Tim Meyer, Alberto Pérez, Jordi Camps, Adam Hospital, Josep Lluis Gelpi, Modesto Orozco. A Consensus View of Protein Dynamics. PNAS 2007 (104) 796-801. [PubMed]
Engineered human myocardium for safety and efficacy screens of cardioactive compounds (2018), Berlin
Video-Optical Analysis of Engineered Human Myocardium in a 48 Well Format Euro Toxicology Meeting (2018) CMBBE meeting, Lisbon.
Engineered Heart Muscle in Drug Screening (2016) Biophysics By The Sea, Port Pollenca
German-Swedish Biophysical Society Meeting, Hünfeld June 22-4, 011. How protein structure and function relate to dynamics
XVII GGMM France Meeting, La Rochelle May 30 + June 1, 2011. How protein structure and function relate to dynamics
How protein structure and function relate to dynamics (2011) XVII GGMM France Meeting, La Rochelle
Exascale meeting, Barcelona December 13-15, 2010. Analyzing the dynasome: How do protein structure and function relate to dynamics.
Analyzing the Dynasome: How do protein structure and function relate to dynamics (2010) Exascale meeting, Barcelona
Protein Desolvation under ESI conditions (2009), XVI GGMM meeting, Mittelwihr
XVI GGMM France Meeting, Mittelwihr May, 5-7 2009. Protein Desolvation under ESI conditions
XI Encuentro Peptidico Iberico, Santiago de Compostela, Spain. 6/7 March 2008. The Gas Phase Proteome
The Gas Phase Proteome (2008) XI Encuentro Peptidico Iberico, Santiago de Compostela