Principal Investigator Tim Meyer, PhD
 Tim Meyer, PhD

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Address

Department of Pharmacology and Toxicology
Robert-Koch-Straße 40
37075 Göttingen

Automated Inotropy and Chronotropy Screens in Engineered Human Myocardium

Engineered tissue surrogates offer an animal-free testbed for safety and efficacy screens of cardio active compounds. Standard organ-bath methods are well established but require significant amounts of tissue handling by expert personnel making them prohibitively costly for large scale screening campaigns. Over the past years we have developed and established a novel multi titer plate that allows to make, grow, and analyze up to 48 tissue constructs in parallel. Analysis and stimulation can be done video-optically, sterility can be maintained unlike in organ bath measurements multiple analysis long-term culture and treatment period can be taken.

3D Extrusion Bioprinting

The driving force of our research is to bring our research from the lab into the clinic, as currently under way with our engineered heart muscle patches. To gain flexibility in design and individualization of large patches we are developing a 3D extrusion bio-printing system. The aim is to create patches made up of interwoven muscle fibers with defined force pattern.

Available for research student supervision? Yes.

Selected Publications

  • Tim Meyer, Malte Tiburcy, WH Zimmermann. Cardiac macrotissues-on-a-plate models for phenotypic drug screens. Adv Drug Deliv Rev. 2019, doi: 10.1016/j.addr.2019.03.002[PubMed]    
  • Montse Barbany, Tim Meyer, .., Xavier de la Cruz. Molecular dynamics study of naturally existing cavity couplings in proteins. PLoS One. 2015 doi: 10.1371/journal.pone.0119978. [PubMed]
  • Malte Tiburcy, Tim Meyer, PL Soong, WH Zimmermann. Collagen-based engineered heart muscle. Methods Mol Biol. 2014 doi: 10.1007/978-1-4939-1047-2_15. [PubMed]
  • Tim Meyer, Valérie Gabelica, Helmut Grubmüller, Modesto Orozco. Proteins in the gas phase Interdisciplinary Reviews: Computational Molecular Science 2012 DOI 10.1002/wcms.1130 [Wiley Online Library]
  • Ulf Hensen, Tim Meyer, Jürgen Haas, René Rex, Gert Vriend, Helmut Grubmüller. Exploring protein dynamics space: The dynasome as the missing link between structure and function. PloS ONE 2012 (7) e33931. [PubMed]
  • Tim Meyer, Marco D’Abramo, Adam Hospital, Manuel Rueda, Carles Ferrer-Costa, Alberto Perez, Oliver Carrillo, Jordi Camps, Carles Fenollosa, Dmitry Repchevsky, Josep Lluis Gelpı, and Modesto Orozco, MoDEL (Molecular Dynamics Extended Library): A Database of Atomistic Molecular Dynamics Trajectories. Structure 2010 (11) 1399 - 1409. [PubMed]
  • Tim Meyer, Xavier de la Cruz, Modesto Orozco. An Atomistic View to the Gas Phase Proteome. Structure 2009 (17) 88-95. [PubMed]
  • Manuel Rueda, Carles Ferrer-Costa, Tim Meyer, Alberto Pérez, Jordi Camps, Adam Hospital, Josep Lluis Gelpi, Modesto Orozco. A Consensus View of Protein Dynamics. PNAS 2007 (104) 796-801. [PubMed]

Conference Talks

  • Engineered human myocardium for safety and efficacy screens of cardioactive compounds (2018), Berlin
  • Video-Optical Analysis of Engineered Human Myocardium in a 48 Well Format Euro Toxicology Meeting (2018) CMBBE meeting, Lisbon.
  • Engineered Heart Muscle in Drug Screening (2016) Biophysics By The Sea, Port Pollenca
  • German-Swedish Biophysical Society Meeting, Hünfeld June 22-4, 011. How protein structure and function relate to dynamics
  • XVII GGMM France Meeting, La Rochelle May 30 + June 1, 2011. How protein structure and function relate to dynamics
  • How protein structure and function relate to dynamics (2011) XVII GGMM France Meeting, La Rochelle
  • Exascale meeting, Barcelona December 13-15, 2010. Analyzing the dynasome: How do protein structure and function relate to dynamics.
  • Analyzing the Dynasome: How do protein structure and function relate to dynamics (2010) Exascale meeting, Barcelona
  • Protein Desolvation under ESI conditions (2009), XVI GGMM meeting, Mittelwihr
  • XVI GGMM France Meeting, Mittelwihr May, 5-7 2009. Protein Desolvation under ESI conditions
  • XI Encuentro Peptidico Iberico, Santiago de Compostela, Spain. 6/7 March 2008. The Gas Phase Proteome
  • The Gas Phase Proteome (2008) XI Encuentro Peptidico Iberico, Santiago de Compostela

Members Meyer Group

PhD Student

Pierre-Luc Satin

 Pierre-Luc Satin

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PhD Student

Maximilian Bieker

Master Student

Emese Zavodszky

 Emese Zavodszky
Technical Assistant

Daniela Liebig-Wolter

 Daniela Liebig-Wolter

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Postdoctoral Researcher

Gesine Marie Dittrich, MD

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HAWK, BA Student

Moritz Burg

Uni Magdeburg, BA Student

Yas Morshedi

Alumni

  • Dr. Romina D’Almeida, Current Position: Research Assistant, INSIBIO - CONICET (National Scientific and Technical Research Council), Buenos Aires, Argentina
  • Harithaa Anandakumar, M. Sc.
  • Maria Kalil Filló
  • Sven Gitte, M. Sc.
  • Lennart Greve, B. Sc., Masterstudent Präzisionsmaschinenbau HAWK Göttingen
  • Chris Knopp, B. Sc.
  • Manuel Kriehn, B. Sc., Masterstudium Präzisionsmaschinenbau, Göttingen
  • Golo Reindel, B. Sc.
  • Dr. Anke Renger, Current Position: Science Leadership Coach, Berlin and Research Assistant Didactics of Biology, University Hamburg
  • Hortense Sagnard
  • Markus Suhr, M. Sc., Consultant Data Engineering & Machine Learning, NextLytics AG, Rendsburg
  • Tobias Weber

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